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Dissertation
Chez le chien souffrant d'arthrose, quels sont les effets de l'injection intra-articulaire d'acide hyaluronique comparés à ceux du carprofène en termes de pharmacodynamie, de conséquences sur le cartilage et d'efficacité analgésique ?
Authors: --- --- --- --- --- et al.
Year: 2024 Publisher: Liège Université de Liège (ULiège)

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Abstract

Carprofen inhibits certain pro-inflammatory genes and stimulates the in vitro 
production of glycosaminoglycans. However, it has chondrotoxicity that depends on 
its intra-articular concentration. Hyaluronic acid increases intra-articular viscosity and 
has anti-inflammatory and immunomodulatory effects. It preserves arthritic 
chondrocytes without affecting healthy ones.
Intra-articular injection of hyaluronic acid is more effective at reducing pain and 
lameness than carprofen, although guidelines on viscosupplementation are unclear. 
Nonetheless, carprofen remains preferred for treating osteoarthritis due to its rare 
side effects and analgesic efficacy. The administration of intra-articular hyaluronic 
acid requires anesthesia for each injection and is not commercially available for dogs 
in Belgium, although the therapeutic cascade can be applied.
In conclusion, while both treatments alleviate osteoarthritis pain, it is important to 
consider their respective advantages and disadvantages.


Book
Blood-Derived Products for Tissue Repair/Regeneration
Authors: ---
ISBN: 3039218611 3039218603 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

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