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Cancer --- Cardiovascular toxicology. --- Immunotherapy. --- Cardiovascular toxicity --- Toxicology --- Immunological aspects --- Treatment --- Càncer --- Immunoteràpia
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Cardiotoxicity. --- Antineoplastic Agents --- Radiotherapy --- Immunotherapy --- adverse effects. --- Cardiac Toxicity --- Cardiac Toxicities --- Cardiotoxicities --- Toxicity, Cardiac --- Cancer --- Cardiovascular toxicology. --- Immunotherapy. --- Cardiovascular toxicity --- Toxicology --- Immunological aspects --- Treatment
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Although it is relatively easy to determine the efficacy of a new drug, it is difficult to establish its safety when administered to millions of patients with multifaceted diseases, co-morbidities, sensitivities, and multiple drug use. In Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development, basic and clinical researchers from industry and academia detail the preclinical, clinical, and regulatory principles currently used to assess the cardiac safety of new drugs from their effects on the electrocardiogram (ECG). The authors explain the parameters of cardiac safety at all stages of clinical research and drug development, including both the preclinical and pharmacogenomic aspects generally and the clinical methodologies and technical aspects for investigational drugs based on cardiac repolarization, as defined by the duration of the QTc interval. Additional chapters comprehensively review the application of electrocardiology in clinical research, demonstrating the fundamentals of ECG interpretation in clinical trials, the statistical analysis plans for ECG data obtained in formal clinical trials, and the practical interpretation of the results. Highlights include practical guidance on how to conduct a thorough ECG Trial in New Drug Development, how to use new ECG and web-based technology in clinical research, and how to follow the new FDA requirements for ECG submissions. Authoritative and up-to-date, Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development offers clinical researchers in industry and academia expert practical advice on establishing their product's cardiac safety, predicting regulatory actions, and getting it successfully to market.
Cardiovascular toxicology. --- Heart --- Drugs --- Electrocardiography. --- Effect of drugs on. --- Side effects --- Testing. --- ECG --- EKG --- Electrocardiograms --- Electrodiagnosis --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Cardiovascular pharmacology --- Cardiovascular toxicity --- Toxicology --- Diseases --- Diagnosis --- Electric properties --- Drug effects --- Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Poisoning --- Poisons --- Pharmacology. --- Medical pharmacology --- Medical sciences --- Physiological effect
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Focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.--
Cardiovascular system --- Cardiovascular toxicology. --- Diseases. --- Cardiovascular Diseases --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Cardiovascular toxicity --- Toxicology --- Cardiovascular diseases --- Adverse Cardiac Event --- Cardiac Events --- Major Adverse Cardiac Events --- Adverse Cardiac Events --- Cardiac Event --- Cardiac Event, Adverse --- Cardiac Events, Adverse --- Event, Cardiac --- Diseases --- Molecular aspects.
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Cardiovascular toxicology --- Cardiovascular system --- Cardiovascular pharmacology --- Cardiovascular agents --- Appareil cardiovasculaire --- Pharmacologie cardiovasculaire --- Agents cardiovasculaires --- Diseases --- Chemotherapy --- Maladies --- Chimiothérapie --- Health Sciences --- Cardiology --- Clinical Medicine --- Toxicology --- Cardiac drugs --- Cardiovascular drugs --- Circulatory system --- Vascular system --- Cardiovascular toxicity --- Drug effects --- Effect of drugs on --- Cardiovascular agents. --- Cardiovascular pharmacology. --- Cardiovascular toxicology. --- Chemotherapy. --- Drugs --- Heart --- Pharmacology --- Blood --- Circulation --- Cardiovascular Diseases --- Cardiovascular Agents --- Cardiovascular System --- chemically induced --- adverse effects --- drug effects --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Circulatory System --- Cardiovascular Systems --- Circulatory Systems --- Blood Circulation --- Cardioactive Agents --- Cardioactive Drugs --- Cardiovascular Drugs --- Agents, Cardioactive --- Agents, Cardiovascular --- Drugs, Cardioactive --- Drugs, Cardiovascular --- Sympathomimetics --- toxicologie --- Cardioactive Agent --- Cardioactive Drug --- Cardiovascular Agent --- Cardiovascular Drug --- Agent, Cardioactive --- Agent, Cardiovascular --- Drug, Cardioactive --- Drug, Cardiovascular --- chemically induced. --- adverse effects. --- drug effects. --- Toxicologie cardiovasculaire
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Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. [...] Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications—arrhythmias, heart failure, and even death.
Cardiovascular toxicology. --- Cardiotoxicity. --- Drug-Related Side Effects and Adverse Reactions. --- Antineoplastic Agents. --- Radiotherapy --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Drug Therapy --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- Cardiac Toxicity --- Cardiac Toxicities --- Cardiotoxicities --- Toxicity, Cardiac --- Cardiovascular toxicity --- Toxicology --- adverse effects. --- adverse effects --- toxicity --- Heart --- Effect of drugs on. --- Cardiovascular pharmacology --- Drug effects --- Cardiotoxicity --- Drug-Related Side Effects and Adverse Reactions --- Antineoplastic Agents --- adverse effects ǂ0 (DNLM)D011878Q000009
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