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Effective new treatments - from drugs to surgery to devices - are revolutionizing both outcome and wellbeing in patients with heart failure. Written with the non-specialist in mind, this practical resource distills a lot of complex information into a refreshingly readable format, with clear informative diagrams and useful pull-out tables. Highlights include: • a concise discussion of the pathophysiological mechanisms that lead to heart failure • a detailed review of the causes and comorbidities of heart failure • simple advice on diagnosis and investigation • clear management principles, including healthy lifestyle choices for patients • evidence-based guidance on first- and second-line drug therapies and medical management that targets the underlying cause • a comprehensive overview of non-pharmacological treatment options, including devices and transplantation • important information on palliative care in end-stage heart failure. 'Fast Facts: Heart Failure' is the ideal resource for primary care providers, specialist nurses and cardiology trainees, and a good introduction to heart failure for all healthcare professionals who care for the elderly. Contents: • Definitions and epidemiology • Pathophysiology and clinical stages • Causes • Comorbidities • Diagnosis • General management and lifestyle considerations • Pharmacological treatment • Non-pharmacological treatment • Prognosis • Clinical trials and developments • Useful resources
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With cardiometabolic diseases still topping the list of mortality causes and in facing the obesity and diabetes epidemic, there remains a great need to better understand the pathophysiological derangements underlying these conditions. During the past years, it has become increasingly appreciated that low grade systemic inflammation is a common hallmark of cardiometabolic disorders--not only concerning diabetes and atherosclerotic cardiovascular disease but also involving non-alcoholic fatty liver disease. Recently developed high-throughput laboratory techniques for lipidomics and metabolomics have enabled researchers to discern novel crosstalk pathways between lipid phenotypes and enhanced chronic inflammation. With this Special Issue of the Journal of Clinical Medicine, entitled "Novel Aspects of Lipoprotein Metabolism with a Focus on Systemic Inflammation", researchers were invited to submit original papers and reviews on various topics, in particular, at the interface of lipid metabolism and inflammation.
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