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This concise and accessible systems-based text provides an integrated overview which considers both the basic sciences and clinical applications of the cardiovascular system. A general introduction to the cardiovascular system is followed by anatomy and histology, blood and body fluids, biochemistry and excitation& contraction coupling, form and function, integration and regulation, and pathology and therapeutics. The Cardiovascular System at a Glance is a perfect introduction and revision aid to understanding the heart and circulation and now also features: An extended section of self-assessment clinical cases to aid revision and illustrate clinical relevance Up-to-date information on pharmacology of the cardiovascular system Expanded material on history and examination and increased detail on ECG of arrhythmias Highly visual colour presentation

Blood physiology. Circulatory physiology --- Pathology of the circulatory system --- Cardiovascular Diseases --- Cardiovascular System --- Cardiovascular Physiological Phenomena --- Cardiovascular system --- anatomy and histology --- Physiology --- Pathophysiology --- Cardiovascular Diseases. --- Cardiovascular Physiology. --- Pathophysiology. --- Physiology. --- anatomy & histology. --- Cardiovascular System - anatomy and histology --- Cardiovascular system - Physiology --- Cardiovascular system - Pathophysiology --- Anatomy & histology.

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It is my great pleasure to publish New Frontiers in Lifestyle-Related Dis­ eases, the proceedings of the Showa University International Symposium for Life Sciences, 3rd Annual Meeting, held at Showa University on Sep­ tember 13, 2006. This symposium was supported, in part, by Grants for the Promotion of the Advancement of Education and Research in Graduate Schools and Ordinary Expenses for Private Schools from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. On behalf of Showa University, I would like to express my deepest thanks to all the authors and editors for their great contribution to the publication of this memorable book that accelerates research activity in lifestyle-related diseases. Akiyoshi Hosoyamada, M.D., Ph.D. President, Showa University Tokyo, Japan September 2007 v Preface The leading cause of death in Western countries and some developing countries is atherosclerotic cardiovascular diseases. Among them, acute myocardial infarction is the most common type of fatal disease, caused by the progression of atherosclerosis characterized by accumulation of choles­ terol in vascular walls. Development of atherosclerosis is greatly enhanced by major risk factors for cardiovascular diseases such as obesity, hyperlip­ idemia, diabetes (hyperglycemia), and hypertension. Among those, obesity frequently initiates a metabolic change that subsequently induces hyperlip­ idemia, diabetes, hypertension, and eventually atherosclerotic cardiovascu­ lar diseases. Because obesity and its related disorders largely depend on lifestyle factors such as high calorie intake and low physical activity, a series of disorders are termed lifestyle-related diseases.

Medicine & Public Health. --- Medical Biochemistry. --- Endocrinology. --- Medicine. --- Biochemistry. --- Médecine --- Endocrinologie --- Biochimie --- Atherosclerosis -- Congresses. --- Atherosclerosis -- metabolism -- Congresses. --- Cardiovascular system -- Pathophysiology -- Congresses. --- Cholesterol, LDL -- metabolism -- Congresses. --- Coronary Disease -- metabolism -- Congresses. --- Homeostasis -- physiology -- Congresses. --- Risk Factors -- Congresses. --- Sleep Apnea Syndromes -- metabolism -- Congresses. --- Cardiovascular system --- Atherosclerosis --- Pathophysiology --- Circulatory system --- Vascular system --- Internal medicine. --- Medical biochemistry. --- Internal Medicine. --- Blood --- Circulation --- Internal medicine --- Hormones --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Medicine, Internal --- Medicine --- Composition --- Endocrinology . --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology

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Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine.  The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis.  Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms.  Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.

Cardiovascular system -- Aging. --- Cardiovascular system -- Pathophysiology. --- Molecular biology. --- Cardiovascular system --- Cardiovascular Diseases --- Diseases --- Vascular Diseases --- Medicine --- Health & Biological Sciences --- Pathology --- Pathophysiology --- Blood-vessels --- Medical genetics. --- Pathology, Molecular. --- Medical innovations. --- Diseases. --- Treatment. --- Innovations, Medical --- Molecular pathology --- Molecular biochemistry --- Molecular biophysics --- Clinical genetics --- Heredity of disease --- Angiology --- Vascular system --- Vasculature --- Vascular diseases --- Innovations --- Technological innovations --- Genetic aspects --- Medicine. --- Cardiology. --- Pathology. --- Medicine & Public Health. --- Molecular Medicine. --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medical technology --- Molecular biology --- Physiology, Pathological --- Human genetics --- Medical sciences --- Genetic disorders --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Heart --- Internal medicine --- Disease (Pathology) --- Medicine, Preventive --- Health Workforce