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Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology.  The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome.  Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions.  Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology.  It is an invaluable reference for cardiology researchers and practitioners.

Cardiovascular System -- embryology. --- Cardiovascular system -- Evolution. --- Cardiovascular system -- Molecular aspects. --- Cardiovascular system --Diseases -- Genetic aspects. --- Heart -- Evolution. --- Heart -- Molecular aspects. --- Cardiovascular system --- Cellular signal transduction --- Biochemical Processes --- Cardiovascular Diseases --- Cell Physiological Processes --- Cardiovascular System --- Biological Science Disciplines --- Biochemical Phenomena --- Diseases --- Cell Physiological Phenomena --- Natural Science Disciplines --- Chemical Processes --- Anatomy --- Disciplines and Occupations --- Chemical Phenomena --- Phenomena and Processes --- Signal Transduction --- Heart --- Heart Diseases --- Physiology --- Medicine --- Health & Biological Sciences --- Pathophysiology --- Cellular signal transduction. --- Diseases. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cardiovascular diseases --- Medicine. --- Cardiology. --- Medical biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Internal medicine --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology