Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

cardiooncology --- cardiotoxicity --- antracyclines --- biomarkers --- GPCR (G protein coupled receptors) --- epigenetics (methylation/demethylation) --- HPSC-cardiomyocytes --- HDLP

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cardiotoxicity. --- Antineoplastic Agents --- Radiotherapy --- Immunotherapy --- adverse effects. --- Cardiac Toxicity --- Cardiac Toxicities --- Cardiotoxicities --- Toxicity, Cardiac --- Cancer --- Cardiovascular toxicology. --- Immunotherapy. --- Cardiovascular toxicity --- Toxicology --- Immunological aspects --- Treatment

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protein, lipid and DNA oxidation, leads to Fe-mediated programmed cell death and organ dysfunction. Major and systemic Fe overloads occurring in hemochromatosis and Fe-loading anemias have been extensively studied. However, localized tissue Fe overload was recently associated to a variety of pathologies, such as infection, inflammation, cancer, cardiovascular and neurodegenerative disorders. In keeping with the existence of cross-regulatory interactions between Fe homeostasis and the pathophysiology of these diseases, further investigations on the mechanisms that provide cellular and systemic adaptation to tissue Fe overload are instrumental for future therapeutic approaches. Thus, we encourage our colleagues to submit original research papers, reviews, perspectives, methods and technology reports to contribute their findings to a current state of the art on a comprehensive overview of the importance of iron metabolism in pathophysiologic conditions.

Iron --- Iron deficiency anemia. --- Metabolism. --- iron metabolism --- iron and genetic disorder --- iron and inflammation --- Heme --- iron and cardiotoxicity --- iron and neurodegeneration --- Iron deficiency and anemia

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer --- Cardiovascular system --- Appareil cardiovasculaire --- Treatment --- Complications --- Periodicals --- Traitement --- Complications et séquelles --- Périodiques --- Cardiology --- Oncology --- Cardiovascular Diseases. --- Cardiotoxicity. --- Neoplasms --- Antineoplastic Agents --- Cardiology. --- Oncology. --- drug therapy. --- adverse effects. --- Cardiac Toxicity --- Cardiac Toxicities --- Cardiotoxicities --- Toxicities, Cardiac --- Toxicity, Cardiac --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- cardiology --- oncology --- cardiotoxicity --- chemotherapy --- Tumors --- Heart --- Internal medicine --- Diseases --- Oncology. Neoplasms --- Pathology of the circulatory system --- Adverse Cardiac Event --- Cardiac Events --- Major Adverse Cardiac Events --- Adverse Cardiac Events --- Cardiac Event --- Cardiac Event, Adverse --- Cardiac Events, Adverse --- Event, Cardiac

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Ischemic heart disease is a cardiovascular condition with very high prevalence worldwide and a major source of morbidity and mortality, especially in the geriatric population. The management of coronary artery disease is one that requires high-level expertise. The presence of comorbidities, usually multiple at advanced ages, makes the diagnosis and therapy very challenging. In this setting, the effort of a multidisciplinary team is urgently needed to achieve integrated management of these cases, being the only one capable of leading to the best results for the patient.The purpose of this reprint is to bring together the experience of specialists in treating ischemic heart disease in the presence of major related conditions that require particular modulations of diagnostic and therapeutic interventions. The chapters address difficult areas of interference between ischemic heart disease and frailty, cancer, liver diseases, inflammatory bowel disease and the new SARS-CoV-2 infection. Special consideration is granted to cardiac remodeling and progression to heart failure. Niche topics such as acute coronary syndromes triggered by carbon monoxide poisoning are present as well. The book also contains a particularly interesting chapter dedicated to the genetic substrate of ischemic heart disease, which once again emphasizes the need for a multidisciplinary team approach to this disease.We consider the reprint an excellent source of information for medical practitioners who have to solve complex cases of ischemic heart disease.

Medicine --- Cardiovascular medicine --- coronary artery disease --- ischemic heart disease --- atherosclerosis --- genetic risk factors --- heritability --- polymorphism --- GWAS --- PRS --- COVID-19 --- myocardial ischemia --- electrocardiography --- accelerated atherosclerosis --- coronary spasm --- coronary thrombosis --- endothelial dysfunction --- cancer --- prevention --- radiotherapy --- chemotherapy --- liver cirrhosis --- prevalence --- liver transplantation --- treatment --- myocardial injury --- cytokines --- biomarkers --- heart failure --- left ventricular remodeling --- myocardial infarction --- wall stress --- inflammation --- neurohormonal activation --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- cardiovascular risk --- frailty --- chronic coronary syndrome --- elderly --- acute coronary syndrome --- carbon monoxide poisoning --- severity of poisoning --- cardiotoxicity --- troponin --- cardiac dysfunction --- non-alcoholic fatty liver disease --- liver-heart axis --- n/a --- Crohn's disease