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Cardiac glycosides --- Cardiac Glycosides --- Congresses. --- congresses.

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Drugs --- Cardenolides --- Cardiac glycosides --- Glucosides --- Administration

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Pharmacology --- Textbooks & monographs 1891-2000. --- Cardiac Glycosides --- Digitalis Glycosides

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In 1775, the physician and botanist William Withering (1741-99) was informed of a folk cure for dropsy that had as its active ingredient the plant foxglove (Digitalis purpurea). Ten years later, after thorough trials on more than 150 patients, Withering published this monograph on the medicinal applications of the plant, not least to keep less experienced doctors from administering it to patients without the proper caution, given the plant's toxicity. Withering was the first doctor to employ foxglove as a remedy for congestive heart failure, which is now the primary disease treated by foxglove-derived pharmaceuticals, and the results from his trials broadly reflect those produced by modern physicians. Withering's first major publication, A Botanical Arrangement of All the Vegetables Naturally Growing in Great Britain (1776), which includes observations on the medicinal applications of British plants, is also reissued in this series.

Digitalis (Drug) --- Edema --- Case studies --- Anasarca --- Dropsy --- Hydrops --- Oedema --- Swelling --- Body fluid disorders --- Digitalis --- Digitalis glycosides --- Cardiac glycosides

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The health benefits of food, plants, fruits, and seaweeds stem from the biological activities of their constituents—namely, secondary metabolites. The study of secondary metabolites and their potential to treat and/or prevent a number of diseases has become a research topic of growing interest for biologists, pharmacists, and chemists. Notably, in order to propose a compound as a potential new drug with pharmacological effects, the chemical structure of this compound and its biological activity against a given target must be well established. The Special Issue, “Isolation and Identification of Bioactive Secondary Metabolites”, considers species beyond their nutritional value and identifies instances of wider and more efficient use, thereby contributing to a more sustainable management of natural resources. The fifteen articles published in this Special Issue reflect the latest research trends, and consider the isolation, identification, and assessment of the beneficial effects of secondary metabolites from both edible and inedible species. Thus, these contributions collectively demonstrate that these compounds, and their plants of origin, should be valued beyond their nutritional benefits.

coumarins --- Lycium --- metabolomic --- HPLC-MS --- orbitrap --- secondary metabolites --- endemic plants --- olive leaves --- supercritical fluid extraction --- antioxidants --- hyperuricemia --- plant-based functional food --- xanthine oxidase --- adenosine deaminase --- uric acid transporter --- bioactive compound --- Piper pseudoarboreum --- bioassay-guided fractionation --- leishmanicidal activity --- alkamides --- (E)-piplartine --- Wedelia chinensis --- organic farming --- phytotoxic substances --- vanillic acid --- gallic acid --- Origanum subspecies --- morphological traits --- glandular trichomes --- essential oil composition --- rosmarinic acid --- sensory evaluation --- colored potato tubers --- total phenols --- anthocyanins --- saccharides --- nutrition --- microelements --- plants --- fungi --- food supplements --- cardiovascular diseases --- neurodegenerative diseases --- Alzheimer’s disease --- metabolic syndrome --- apocarotenoid --- caffeic acid derivative --- flavonoid --- Lactuca sativa --- lignan --- megastigmane --- sesquiterpene lactone --- 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid --- black chokeberry --- anthocyanin --- simulated moving bed --- antioxidant activity --- neuroprotection --- Artemisia --- clinical trials --- health effects --- adverse effects --- anticancer --- antiparasitic --- artemisinin --- santonin --- achillin --- tehranolide --- Aglaomorpha quercifolia --- GC-MS profile --- rhizome --- leaves --- n-hexane extract --- fatty acids --- terpenoids --- linolenic acid --- hop-16-ene --- cardiac glycosides --- secondary plant metabolites --- natural product isolation --- hyrcanoside --- deglucohyrcanoside --- ouabain --- cymarin --- digitoxin --- anticancer activity --- Na+/K+-ATPase inhibitors --- corn salad --- leafy vegetables --- phytochemicals --- liquid chromatography --- mass spectrometry --- celastrol --- Celastraceae --- antimicrobial activity --- mechanism of action --- Bacillus subtilis --- n/a --- Alzheimer's disease