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Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.

Cancer. --- Cancer cells. --- Carcinogenesis. --- Carcinogenesis - Molecular aspects. --- Carcinogens. --- Gene Expression Regulation, Neoplastic. --- Genomic Instability. --- Neoplasms. --- Carcinogenesis --- Cancer cells --- Cancer --- Gene Expression Regulation, Neoplastic --- Genomic Instability --- Carcinogens --- Genetics --- Neoplasms --- Gene Expression Regulation --- Diseases --- Noxae --- Biology --- Pathologic Processes --- Genetic Phenomena --- Mutation --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Genetic Variation --- Phenomena and Processes --- Biological Science Disciplines --- Toxic Actions --- Chemical Actions and Uses --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Molecular aspects --- Pathophysiology --- Genetic aspects --- Molecular aspects. --- Pathophysiology. --- Genetic aspects. --- Cancer genetics --- Molecular carcinogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Cancer genes --- Cells --- Pathology, Cellular --- Pathology, Molecular --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Biomedicine, general. --- Cancer research --- Cancer Biology. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors

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Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

Cancer -- Treatment. --- Carcinogenesis -- Molecular aspects. --- Death receptors -- Molecular aspects. --- Neoplasms -- Etiology. --- Neoplasms -- Therapy. --- Receptors, Death Domain -- Physiology. --- Receptors, Tumor Necrosis Factor -- Physiology. --- Tumor necrosis factor -- Physiological effect. --- Tumor necrosis factor -- Receptors -- Physiological effect. --- Cell receptors --- Carcinogenesis --- Cancer --- Tumor necrosis factor --- Diseases --- Receptors, Cytokine --- Receptors, Cell Surface --- Biological Science Disciplines --- Receptors, Death Domain --- Physiology --- Receptors, Tumor Necrosis Factor --- Neoplasms --- Membrane Proteins --- Receptors, Immunologic --- Natural Science Disciplines --- Disciplines and Occupations --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Medicine --- Biology --- Cytology --- Oncology --- Microbiology & Immunology --- Health & Biological Sciences --- Physiological effect --- Molecular aspects --- Treatment --- Receptors --- Ligands (Biochemistry) --- Cancer. --- Cell death. --- Cell receptors. --- Apoptosis. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Cell degeneration --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Medicine. --- Cancer research. --- Molecular biology. --- Oncology. --- Biochemistry. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Molecular Medicine. --- Biochemistry, general. --- Cell death --- Binding sites (Biochemistry) --- Cell membranes --- Cells --- Death (Biology) --- Tumors --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Biochemistry