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De nieuwe techniek van next generation sequencing heeft het inzicht in het ontstaan van kanker ingrijpend gewijzigd. Reeksen erfelijke aanlegfactoren leiden tot een verhoogd risico op kanker en tumoren tonen typerende patronen van genetische ontregeling.De nieuwe technieken bieden tot nu toe ongekende mogelijkheden van preventie, vroege opsporing en doelgerichte behandeling van kanker. Zij roepen echter ook nieuwe vragen op. Wat zijn de voor- en nadelen van diagnostiek naar erfelijke aanlegfactoren met uitgebreide genpanels? Voor welke patiënten dient de behandeling afgestemd te worden op de uitkomsten van genetische diagnostiek?Multidisciplinaire zorg vormt al lang de ruggengraat van de klinische oncologie. Er worden nu wegen gezocht om de nieuwe genetica in te passen in deze multidisciplinaire benadering.Dit boek biedt een overzicht van de belangrijkste erfelijke tumorsyndromen en van de genoemde ontwikkelingen in de oncogenetica. Het boek is een naslagwerk voor de praktijk en bedoelt voor allen die betrokken zijn bij de oncologische diagnostiek en behandeling.
Genetica --- Oncologie --- schildkliercarcinoom --- huidkanker --- carcinogenen --- ovariumcarcinoom --- neurofibromatose --- prostaatcarcinoom --- longcarcinoom --- maagcarcinoom --- Genetics --- Oncology. Neoplasms --- kwaadaardige gezwellen --- mammacarcinomen --- genetica --- oncologie --- medische genetica --- pancreascarcinoom --- Erfelijkheidsleer
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Bacterial toxins --- Bacteriële toxinen --- Cancer causing agents --- Carcinogenen --- Carcinogenic agents --- Carcinogens --- Carcinogènes --- Oncogens --- Toxinen [Bacteriële ] --- Toxines bactériennes --- Cyanobacterial toxins --- Nitrates --- Nitrate salts --- Nitric acid --- Oxysalts --- Blue-green algal toxins --- Cyanobacteria toxins --- Cyanotoxins
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Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.
Cancer causing agents --- Carcinogenen --- Carcinogenic agents --- Carcinogens --- Carcinogènes --- Facteurs de transcription --- Factoren [Transcriptie] --- Genetic transcription factors --- Omleggingen (Erfelijkheid) --- Oncogens --- Transcriptiefactoren --- Transcription [Facteurs de ] --- Transcription factors --- Translocaties (Erfelijkheid) --- Translocation (Genetics) --- Translocations (Génétique) --- Transposities (Erfelijkheid) --- Transposition (Genetics) --- Transpositions (Génétique) --- Translocation, Genetic --- GENE EXPRESSION REGULATION --- Oncogenes --- physiology --- GENE EXPRESSION REGULATION. --- Oncogenes. --- physiology. --- Physiology. --- Immunology. --- Virology. --- Cell biology. --- Molecular biology. --- Cancer research. --- Cell Biology. --- Molecular Medicine. --- Cancer Research. --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cell biology --- Cellular biology --- Biology --- Cells --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Chromosomes --- Genetics
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Cancer causing agents --- Carcinogenen --- Carcinogenic agents --- Carcinogens --- Carcinogènes --- Combustibles fossiles --- Cookery --- Cooking --- Cuisine --- Cuisiner --- Culinair --- Food preparation --- Fossiele brandstoffen --- Fossil energy --- Fossil fuels --- Gerechten --- Koken --- Kookkunst --- Oncogens --- Poisons--Testing --- Tests [Toxicologische ] --- Toxiciteit--Tests --- Toxiciteitstests --- Toxicity testing --- Toxicité [Tests de ] --- Toxicological testing --- Toxicologische tests --- Toxicology testing --- Toxicology--Testing --- Carcinogens, Environmental --- Frying --- Indoor air pollution --- Lungs --- Stoves, Coal --- Stoves, Wood --- Wood-burning stoves --- Wood stoves --- Biomass stoves --- Coal stoves --- Lung --- Cardiopulmonary system --- Chest --- Respiratory organs --- Air --- Sick building syndrome --- Physiological effect --- Dust diseases --- Tumors --- Health aspects --- Pollution, Indoor --- Pollution --- Research
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Toxicology --- voeding --- voedselvergiftiging --- Food science and technology --- voedselveiligheid --- voedingshygiëne --- Alimentation --- Environnement --- Milieu --- Voeding --- 641.1 --- Academic collection --- 641.1/.3 voeding --- 663/664.004.12 voedselveiligheid --- #A9707A --- additieven --- bewaarmiddelen --- carcinogene stoffen --- contaminanten --- gezondheid --- kleurstoffen --- pesticiden --- radioactiviteit --- toxicologie --- wetgeving --- 628.1 --- Bewaarmiddelen --- Carcinogenen --- Contaminanten --- Geneesmiddelen --- Geurstoffen --- Industriële producten --- Kleurstoffen --- Mutagenen --- Mycotoxinen --- Nitrosaminen --- Pesticiden --- Pyrotoxische stoffen --- Radioactiviteit --- Smaakstoffen --- Technologische stoffen --- Teratogenen --- Toxicologie --- Vreemde stoffen --- Zware metalen --- contaminatie --- voedingsmiddelen --- 613.2 --- 628.5 --- Additieven --- Metalen-zware --- Toxiciteit --- Toxicologie (vergiftiging, intoxicatie) --- Voedingshygiëne --- Voedselcontrole --- levensmiddelensector --- voedingsindustrie --- 628.4 --- 664 --- Voeding : gevaarlijke stoffen --- antibiotica --- cadmium --- carcinogenen --- fluor --- groeihormoon --- hormonen --- koolwaterstoffen --- loodintoxicatie (bloedloodwaarden) --- metaalintoxicaties --- nitraat --- nitriet --- smaak --- toxicologie (intoxicatie, vergiftiging) --- voedingshygiëne (voedingsgewoonten) --- voedingsleer --- ecotoxicologie --- pesticide --- toxine --- voedingsadditief --- voedselchemie --- zware metalen --- Voeding en toxicologie --- Voedingsleer --- Foodstuffs from the point of view of properties. Nutritional value --- Alimentation/Nutrition --- Kennis van voedings- en genotmiddelen; algemeen --- levensmiddelen --- (zie ook: sportvoeding) --- (zie ook: beroepskanker) --- (zie ook: endocrinologie) --- (zie ook: bedrijfshygiëne) --- (zie ook: voedingshygiëne) --- (zie ook: bestrijdingsmiddel) --- Agrotechnology and Food Sciences. Food Sciences --- Food Chemistry --- Chemistry of Food Components --- 641.1 Foodstuffs from the point of view of properties. Nutritional value --- Chemistry of Food Components. --- Food --- Analysis --- Quality --- Food contamination --- 620 --- alimentation
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diagnostiek (geneeskunde) --- arbeidsbelasting --- Personnel management --- ergonomie --- arbeid --- Sociology of work --- ziekteverzuim --- beroepsziekten --- gezondheid --- geluidshinder --- arbeidsomstandigheden --- bedrijfshygiëne --- ongevallen --- Hygiene. Public health. Protection --- personen met een beperking --- Industrial hygiene --- -Quality of work life --- -#SBIB:316.334.2A82 --- #SBIB:316.334.2A81 --- #KVHB:Gezondheidspsychologie --- #KVHB:Arbeids- en organisatiepsychologie --- 614.3 --- arbeidsbescherming (bedrijfsveiligheid) --- arbeidsgeneeskunde (bedrijfsgeneeskunde) --- arbeidsongeschiktheid --- arbeidsongevallen --- arbeidssociologie (bedrijfssociologie) --- carcinogenen --- dienstrooster (uurrrooster) --- stress --- vrouwenarbeid --- Humanization of work life --- Quality of working life --- Work life, Quality of --- Working life, Quality of --- Quality of life --- Work --- Employees --- Health of workers --- Hygiene, Industrial --- Industrial health engineering --- Occupational health and safety --- Occupational safety and health --- Occupations --- Work environment --- Environmental health --- Industrial management --- Medicine, Industrial --- Bijzondere arbeidsproblemen: ergonomie, arbeidsgeneeskunde, arbeidsbelasting, arbeidsongeschiktheid, burn-out --- Bijzondere arbeidsproblemen: arbeidsongevallen, veiligheid --- (zie ook: beroepskanker) --- Health and hygiene --- Health aspects --- Quality of work life --- Arbeids- en organisatiepsychologie --- arbeidsmarkt --- arbeidsmarkt. --- Arbeidsmarkt. --- #SBIB:316.334.2A82
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Cancer causing agents --- Carcinogenen --- Carcinogenic agents --- Carcinogens --- Carcinogènes --- Mycotoxicosen --- Mycotoxicoses --- Oncogens --- Carcinogens, Environmental. --- Mycotoxins --- Nitroso Compounds --- Tobacco Smoke Pollution. --- Tobacco smoke --- -Mycotoxins --- -Kanker --- Tabak --- Toxicologie --- Chemische stoffen --- Fungal toxins --- Fungal metabolites --- Microbial toxins --- Toxigenic fungi --- Smoke --- Cotinine --- Environmental Smoke Pollution, Tobacco --- Environmental Tobacco Smoke Pollution --- Involuntary Smoking --- Second Hand Smoke --- Secondhand Smoke --- Secondhand Smoking --- Air Pollution, Tobacco Smoke --- Environmental Pollution, Tobacco Smoke --- Passive Smoking --- Smoking, Passive --- Hand Smoke, Second --- Hand Smokes, Second --- Involuntary Smokings --- Passive Smokings --- Pollution, Tobacco Smoke --- Pollutions, Tobacco Smoke --- Second Hand Smokes --- Secondhand Smokes --- Secondhand Smokings --- Smoke Pollution, Tobacco --- Smoke Pollutions, Tobacco --- Smoke, Second Hand --- Smoke, Secondhand --- Smokes, Second Hand --- Smokes, Secondhand --- Smoking, Involuntary --- Smoking, Secondhand --- Smokings, Involuntary --- Smokings, Passive --- Smokings, Secondhand --- Tobacco Smoke Pollutions --- Smoking --- Air Pollution, Indoor --- Environmental Carcinogens --- Environmental Pollutants --- adverse effects. --- Congresses --- Carcinogenicity --- -Congresses --- Cancer --- Tabac --- Produits chimiques --- Nitroso compounds --- Carcinogens, Environmental --- Tobacco Smoke Pollution --- Kanker --- adverse effects --- Nitroso-compounds --- Toxicology --- Tobacco --- Risk factors --- Tobacco use --- Health aspects
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toxicologie --- Human genetics --- Toxicology --- Pharmacology. Therapy --- Oncology. Neoplasms --- pharmacology --- farmacologie --- biologie --- toxicology --- mutaties --- Hygiene. Public health. Protection --- Environmental protection. Environmental technology --- aangeboren afwijkingen --- antropogenetica --- Ecologie --- Erfelijkheidsleer --- Hérédité --- 575.224 --- 614.7 --- 504.75 --- Genetic toxicology --- Health risk assessment --- #KVIV --- #ECO:01.13:economie sociaal duurzaam milieu ethiek --- $?$88/12 --- 575.17 --- 575.224.46.044 --- 612.6.05 --- 575 --- 502.5:575.2 --- ecologie --- genetica --- genotoxiciteit --- milieubeheer --- 504 --- 600.2 --- 605.99 --- 614.2 --- 614.62 --- DNA --- chromosomen --- geneeskunde --- geneesmiddelen --- genetisch risico --- gezondheidszorg --- leefmilieu --- metalen --- milieu --- mutagenen --- oncologie --- roken --- Gezondheidszorg --- Milieuhygiëne --- Reproduktietoxicologie --- 504.054 --- 575.1 --- 614.3 --- Milieuvervuiling : erfelijkheid --- carcinogenen --- koolwaterstoffen --- metaalintoxicaties --- milieuhygiëne --- pesticiden --- tabak --- Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Medicine, Preventive --- Public health --- Risk assessment --- Environmental health --- Genotoxicity --- Genotoxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Mutations. Mutagenesis. Mutagens. --- Pollutie van lucht, water, grond--(openbare gezondheidszorg) --- Human ecology and human environment --- erfelijkheid --- milieu - leefmilieu - milieubeleid (zie ook 712) - duurzame ontwikkeling --- Milieuwetenschappen --- Andere speciale ziekten - Genetologie - Aangeboren en erfelijke afwijkingen - Chronische ziekten --- Maatschappelijke gezondheidszorg voor afzonderlijke groepen --- Milieuverontreiniging --- (zie ook: beroepskanker) --- Genetic aspects --- Genetic toxicology. --- Health risk assessment. --- Gevaarlijke stoffen --- Risico-analyse --- Gevaarlijke stoffen. --- Risico-analyse. --- 575.224 Mutations. Mutagenesis. Mutagens. --- 504.75 Human ecology and human environment --- Mutations. Mutagenesis. Mutagens --- Genetica --- Génétique --- Verontreiniging. Toxicologie. --- Verontreiniging. Genetische aspecten. --- Pollution. Toxicologie. --- Pollution. Aspects génétiques.
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