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Carbonic anhydrase. --- Carbonic Anhydrases --- chemistry. --- pharmacokinetics. --- Carbonate dehydratase --- Lyases --- Zinc enzymes

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Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalystsIncludes current applications of carbonic anhydrases in biotechnology on the basis of their

Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Carbonic anhydrase. --- Carbonic anhydrase --- Enzymes. --- Enzymes --- Biotechnology. --- Therapeutic use. --- Chemical engineering --- Genetic engineering --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Carbonate dehydratase --- Lyases --- Zinc enzymes

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This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed. .

Carbonic anhydrase. --- Carbonate dehydratase --- Lyases --- Zinc enzymes --- Medicine. --- Biochemistry. --- RNA-ligand interactions. --- Pharmaceutical technology. --- Molecular Medicine. --- Medical Biochemistry. --- Protein-Ligand Interactions. --- Medicinal Chemistry. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Health Workforce --- Composition --- Molecular biology. --- Medical biochemistry. --- Proteins . --- Medicinal chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Systems biology