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Silicon Carbide (SiC) is a wide-band-gap semiconductor biocompatible material that has the potential to advance advanced biomedical applications. SiC devices offer higher power densities and lower energy losses, enabling lighter, more compact and higher efficiency products for biocompatible and long-term in vivo applications ranging from heart stent coatings and bone implant scaffolds to neurological implants and sensors. The main problem facing the medical community today is the lack of biocompatible materials that are also capable of electronic operation. Such devices are currently implemented using silicon technology, which either has to be hermetically sealed so it cannot interact with the body or the material is only stable in vivo for short periods of time. For long term use (permanent implanted devices such as glucose sensors, brain-machine-interface devices, smart bone and organ implants) a more robust material that the body does not recognize and reject as a foreign (i.e., not organic) material is needed. Silicon Carbide has been proven to be just such a material and will open up a whole new host of fields by allowing the development of advanced biomedical devices never before possible for long-term use in vivo. This book provides not only the materials and biomedical engineering communities with a seminal reference book on SiC that they can use to further develop the technology, but to also provide a technology resource for medical doctors and practitioners who are hungry to identify and implement advanced engineering solutions to their everyday medical problems that currently lack long term, cost effective solutions. Discusses Silicon Carbide biomedical materials and technology in terms of their properties, processing, characterization, and application, in one book, from leading professionals and scientists Critical assesses existing literature, patents and FDA approvals for clinical trials, enabling the rapid assimilation of important data from the current disparate sources and promoting the transition from technology research and development to clinical trials Explores long-term use and applications in vivo in devices and applications with advanced sensing and semiconducting properties, pointing to new product devekipment particularly within brain trauma, bone implants, sub-cutaneous sensors and advanced kidney dialysis devices.

Human biochemistry --- Materials sciences --- Biocompatible Materials --- Carbon Compounds, Inorganic --- Semiconductors --- Silicon Compounds

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Organic compounds --- Carbon --- Carbon compounds --- Carbon Compounds, Inorganic --- Carbon. --- Carbon compounds. --- Organic compounds. --- Inorganic Chemistry

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Organic compounds --- Carbon --- Carbon compounds --- Carbon Compounds, Inorganic --- Carbon. --- Carbon compounds. --- Organic compounds. --- Group 14 elements --- Light elements --- Compounds, Organic --- Organic chemicals --- Chemicals --- Inorganic Carbon Compounds --- Compounds, Inorganic Carbon --- Carbon-12 --- Vitreous Carbon --- Carbon 12 --- Carbon, Vitreous --- Inorganic Chemistry --- Chemistry --- General and Others

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Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters.

Cellular signal transduction. --- Gases -- Physiological effect. --- Neurosciences. --- Signal transduction. --- Sulfur Compounds --- Nitrogen Oxides --- Reactive Nitrogen Species --- Biochemical Processes --- Carbon Compounds, Inorganic --- Oxides --- Physiological Effects of Drugs --- Free Radicals --- Cell Physiological Processes --- Gases --- Molecular Mechanisms of Pharmacological Action --- Acids, Noncarboxylic --- Chemical Processes --- Inorganic Chemicals --- Pharmacologic Actions --- Cell Physiological Phenomena --- Nitrogen Compounds --- Acids --- Biochemical Phenomena --- Oxygen Compounds --- Chemical Phenomena --- Chemicals and Drugs --- Chemical Actions and Uses --- Phenomena and Processes --- Neurotransmitter Agents --- Nitric Oxide --- Carbon Monoxide --- Signal Transduction --- Hydrogen Sulfide --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Physiology --- Physiological effect. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Medicine. --- Human physiology. --- Biochemistry. --- Cell physiology. --- Cell membranes. --- Biomedicine. --- Human Physiology. --- Cell Physiology. --- Animal Biochemistry. --- Membrane Biology. --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell function --- Cytology --- Neural sciences --- Neurological sciences --- Nervous system --- Human biology --- Human body --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Composition --- Cell membranes .