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Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been

Anti-Bacterial agents -- Biosynthesis. --- Biological products -- Biosynthesis. --- Carbohydrates -- Biosynthesis. --- Peptide Biosynthesis --- Biological Products --- Anti-Bacterial Agents --- Polyketide Synthases --- Enzymes --- Carbohydrates --- Complex Mixtures --- Enzymes and Coenzymes --- Anti-Infective Agents --- Biochemical Processes --- Multienzyme Complexes --- Metabolism --- Chemicals and Drugs --- Carbon-Carbon Ligases --- Biochemical Phenomena --- Ligases --- Therapeutic Uses --- Metabolic Phenomena --- Chemical Processes --- Phenomena and Processes --- Chemical Phenomena --- Pharmacologic Actions --- Chemical Actions and Uses --- Biosynthesis. --- Peptides --- Polyketides --- Synthesis. --- Microbial biotechnology. --- Carbs (Carbohydrates) --- Peptide synthesis --- Acetogenins --- Biological synthesis --- Synthesis, Biological --- Microorganisms --- Biotechnology --- Biomolecules --- Organic compounds --- Glycomics --- Ketenes --- Polymers --- Biochemical engineering --- Biochemistry --- Synthetic biology --- Biochemical templates --- Industrial microbiology --- Biotechnological microorganisms --- Synthesis