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Book
Capsaicin as a Therapeutic Molecule
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ISBN: 3034808283 3034808275 Year: 2014 Publisher: Basel : Springer Basel : Imprint: Springer,

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Abstract

This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors, and gastrointestinal, dermatologic, and urologic disorders. It discusses the basic functions  of  the capsaicin receptor (TRPV1), its mechanisms of action, and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material  on the subject that will stimulate future research.


Book
Role of capsaicin in oxidative stress and cancer
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ISBN: 9401784299 9400763166 9400763174 Year: 2013 Publisher: Dordrecht : Springer,

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Abstract

Capsaicin is a principal pungent ingredient of red chili peppers, first isolated in the early nineteenth century by Christian Friedrich Bucholz. Widely consumed as a spice in South Asia and Latin America, Capsaicin has been used to treat pain and inflammation associated with a variety of diseases, including rheumatoid arthritis, diabetic neuropathy, post-masectomy pain, cluster headaches, and herpes zoster. Although recent studies have evaluated capsaicin as a novel anti-cancer agent, and mechanisms of capsaicin in preventing cancer have been described sporadically, the literature lacks a comprehensive review of capsaicin as a chemo-preventive agent. Role of Capsaicin in Oxidative Stress and Cancer offers a thorough exploration of the preventive and therapeutic effects of capsaicin in cancer models such as melanoma, pancreatic cancer, colon cancer, gastric cancer, breast cancer, prostate cancer, skin cancer, lung cancer, multiple myeloma and glioma.  The contributors, all internationally recognized researchers, identify various molecular and cellular targets of capsaicin, and show the critical role of mitochondria in capsaicin-mediated therapeutic effects. Readers will learn how capsaicin prevents or may treat cancer, how different cells respond to capsaicin, how environmental carcinogen-induced carcinogenesis can be prevented by capsaicin and the mechanism of oxidative stress caused by capsaicin.  This book will benefit medical students, oncologists and cancer researchers everywhere.

Keywords

Catechols --- Protective Agents --- Polyunsaturated Alkamides --- Solanaceous Alkaloids --- Diseases --- Therapeutic Uses --- Fatty Acids, Monounsaturated --- Stress, Physiological --- Metabolism --- Fatty Acids, Unsaturated --- Physiological Processes --- Metabolic Phenomena --- Amides --- Alkaloids --- Physiological Effects of Drugs --- Phenols --- Alkenes --- Pharmacologic Actions --- Specialty Uses of Chemicals --- Heterocyclic Compounds --- Chemical Actions and Uses --- Phenomena and Processes --- Organic Chemicals --- Fatty Acids --- Physiological Phenomena --- Hydrocarbons, Acyclic --- Lipids --- Chemicals and Drugs --- Hydrocarbons --- Neoplasms --- Capsaicin --- Antineoplastic Agents --- Oxidative Stress --- Anticarcinogenic Agents --- Medicine --- Health & Biological Sciences --- Oncology --- Capsaicin. --- Oxidative stress. --- Axsain (Trademark) --- Capsaicine --- Capsidol (Trademark) --- Capsin (Trademark) --- Capzasin (Trademark) --- Gelcen (Trademark) --- Katrum (Trademark) --- NGX-4010 (Trademark) --- Qutenza (Trademark) --- Zacin (Trademark) --- Zostrix (Trademark) --- Medicine. --- Science. --- Cancer research. --- Gene expression. --- Pharmacology. --- Cell biology. --- Apoptosis. --- Biomedicine. --- Cancer Research. --- Science, general. --- Pharmacology/Toxicology. --- Gene Expression. --- Cell Biology. --- Oxidation-reduction reaction --- Stress (Physiology) --- Analgesics --- Capsaicinoids --- Oncology. --- Cytology. --- Toxicology. --- Science, Humanities and Social Sciences, multidisciplinary. --- Genes --- Genetic regulation --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Expression --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cell death --- Cancer research --- Physiological effect

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