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Cancer --- Cancer--Pathogenesis --- Cancers --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Carcinoma --- Carcinome --- Carcinoom --- Kanker --- Kanker--Ontstaan --- Malignancy (Cancer) --- Malignant tumors --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- DNA --- Methylation. --- Genetic aspects. --- Methylation --- Monograph
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Enzymology --- Cancer--Pathogenesis --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Kanker--Ontstaan --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Cancer cells --- Growth --- Cancer --- Genetic aspects --- Gene expression. --- Molecular cloning. --- DNA. --- DNA --- Oncogènes --- Régulation génétique --- Transformation génétique --- Manuels de laboratoire --- Cell proliferation --- Oncogenes --- Protein binding
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Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer provides a current perspective on the epidemiology of head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established associations with tobacco and alcohol use, the human papilloma virus, and potential determinants of genetic susceptibility. Because of these factors, head and neck cancer offers a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction. This book brings together the latest epidemiologic and molecular genetic evidence regarding the patterns of occurrence and causes of head and neck cancer. In addition, Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer considers approaches to chemoprevention, and incorporates a multidisciplinary perspective including salient clinical, pathologic, molecular, and epidemiologic contributions.
Head -- Cancer -- Epidemiology. --- Head -- Cancer -- Pathogenesis. --- Head -- Cancer -- Prevention. --- Neck -- Cancer -- Epidemiology. --- Neck -- Cancer -- Pathogenesis. --- Neck -- Cancer -- Prevention. --- Head --- Neck --- Neoplasms by Site --- Head and Neck Neoplasms --- Neoplasms --- Diseases --- Medicine --- Oncology --- Health & Biological Sciences --- Epidemiology --- Cancer --- Pathogenesis --- Prevention --- Epidemiology. --- Pathogenesis. --- Prevention. --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Figure drawing --- Skull --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect
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Hygiene. Public health. Protection --- Oncology. Neoplasms --- Epidemiology --- Cancer --- Cancer--Pathogenesis --- Cancers --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Carcinoma --- Carcinome --- Carcinoom --- Kanker --- Kanker--Ontstaan --- Malignancy (Cancer) --- Malignant tumors --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Neoplasms --- -Cancer --- -Kanker --- Tumors --- epidemiology --- etiology --- prevention & control --- Prevention --- Etiology --- NEOPLASMS --- WORLD HEALTH ORGANIZATION --- ETIOLOGY --- EPIDEMIOLOGY --- PREVENTION AND CONTROL
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Cancer--Pathogenesis --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Kanker--Ontstaan --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- -Genetic toxicology --- -Reproductive toxicology --- -Toxicology --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Chemical mutagenesis --- Cancer --- Pathology --- Genetic toxicology --- Congresses --- Genetic aspects --- Pathogenesis --- -Congresses --- Reproductive toxicology --- Monograph --- NEOPLASMS --- PRENATAL EXPOSURE DELAYED EFFECTS --- ANIMALS, NEWBORN --- NEOPLASMS, RADIATION-INDUCED --- RISK FACTORS --- MODELS, BIOLOGICAL --- CHEMICALLY INDUCED --- GENETICS
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More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An other reality to emerge from the discovery of Cdks was the ex ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so.
Cancer--Pathogenesis --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Cell proliferation --- Cell renewal --- Cellen--Proliferatie --- Cellular proliferation --- Kanker--Ontstaan --- Oncogenesis --- Pathogenesis of cancer --- Proliferation cellulaire --- Tumorigenesis --- Cyclin kinase --- Inhibitors --- Immunology. --- Cell biology. --- Cancer research. --- Biochemistry. --- Cell Biology. --- Cancer Research. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cancer research --- Cell biology --- Cellular biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Composition
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Cancer--Pathogenesis --- Carcinogenese --- Carcinogenesis --- Carcinogénèse --- Kanker--Ontstaan --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pituitary Neoplasms --- Oncogenes. --- Oncogene --- Transforming Gene --- Transforming Genes --- Gene, Transforming --- Genes, Transforming --- genetics. --- Pituitary gland --- Oncogenes --- Hypophysis cerebri --- Pituitary body --- Brain --- Endocrine glands --- Hypothalamo-hypophyseal system --- Cancer --- Pathology --- Genetic toxicology --- Tumors&delete& --- Molecular aspects --- genetics --- Pathogenesis --- Hypophyse --- Tumors --- Pituitary gland - Tumors - Molecular aspects.
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Prostate cancer is a life-altering diagnosis, not just for patients, but for their loved ones as well. Once, prostate cancer was most frequently diagnosed in men in their 60s and 70s; with increasing use of imaging modalities and PSA testing, the incidence is on the rise, and we are now seeing men in their 40s with the disease. This poses a challenge for clinical management depending on the stage of the disease—from watchful waiting or active surveillance to aggressive treatment with the risk of therapeutic nihilism. Despite being one of the most common cancers in Western men, its natural history, prognosis, and treatment are poorly understood. This book brings together a select faculty of experts to present a comprehensive view of the current state and future perspectives of prostate cancer. There are ten chapters in the book—the first four cover our present knowledge and understanding of the disease, the following three explore new advancements and treatments, particularly looking at overcoming resistance to therapy, and the remaining three chapters focus on specific molecules with the potential to become drug targets. We all have much to learn about prostate cancer. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.
Prostate --- Cancer. --- Epidemiology of Prostate Cancer; Etiology of Prostate Cancer; Pathogenesis of Prostate Cancer; Current Diagnostics for Prostate Cancer; Combination Treatment for Prostate Cancer; Castration-Resistant Prostate Cancer; Theranostics in Metastatic Castrate Resistant Prostate Cancer; Adenocarcinoma of the Prostate; p53 in Prostate Cancer; MUCIN 1 in Prostate Cancer; STEAP Proteins in Prostate Cancer
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Prostate cancer is a life-altering diagnosis, not just for patients, but for their loved ones as well. Once, prostate cancer was most frequently diagnosed in men in their 60s and 70s; with increasing use of imaging modalities and PSA testing, the incidence is on the rise, and we are now seeing men in their 40s with the disease. This poses a challenge for clinical management depending on the stage of the disease—from watchful waiting or active surveillance to aggressive treatment with the risk of therapeutic nihilism. Despite being one of the most common cancers in Western men, its natural history, prognosis, and treatment are poorly understood. This book brings together a select faculty of experts to present a comprehensive view of the current state and future perspectives of prostate cancer. There are ten chapters in the book—the first four cover our present knowledge and understanding of the disease, the following three explore new advancements and treatments, particularly looking at overcoming resistance to therapy, and the remaining three chapters focus on specific molecules with the potential to become drug targets. We all have much to learn about prostate cancer. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.
Prostate --- Cancer. --- Epidemiology of Prostate Cancer; Etiology of Prostate Cancer; Pathogenesis of Prostate Cancer; Current Diagnostics for Prostate Cancer; Combination Treatment for Prostate Cancer; Castration-Resistant Prostate Cancer; Theranostics in Metastatic Castrate Resistant Prostate Cancer; Adenocarcinoma of the Prostate; p53 in Prostate Cancer; MUCIN 1 in Prostate Cancer; STEAP Proteins in Prostate Cancer
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Prostate cancer is a life-altering diagnosis, not just for patients, but for their loved ones as well. Once, prostate cancer was most frequently diagnosed in men in their 60s and 70s; with increasing use of imaging modalities and PSA testing, the incidence is on the rise, and we are now seeing men in their 40s with the disease. This poses a challenge for clinical management depending on the stage of the disease—from watchful waiting or active surveillance to aggressive treatment with the risk of therapeutic nihilism. Despite being one of the most common cancers in Western men, its natural history, prognosis, and treatment are poorly understood. This book brings together a select faculty of experts to present a comprehensive view of the current state and future perspectives of prostate cancer. There are ten chapters in the book—the first four cover our present knowledge and understanding of the disease, the following three explore new advancements and treatments, particularly looking at overcoming resistance to therapy, and the remaining three chapters focus on specific molecules with the potential to become drug targets. We all have much to learn about prostate cancer. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.
Prostate --- Epidemiology of Prostate Cancer; Etiology of Prostate Cancer; Pathogenesis of Prostate Cancer; Current Diagnostics for Prostate Cancer; Combination Treatment for Prostate Cancer; Castration-Resistant Prostate Cancer; Theranostics in Metastatic Castrate Resistant Prostate Cancer; Adenocarcinoma of the Prostate; p53 in Prostate Cancer; MUCIN 1 in Prostate Cancer; STEAP Proteins in Prostate Cancer --- Cancer.
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