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Tumor Microenvironment. --- Extracellular Matrix. --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Matrix, Extracellular --- Extracellular Matrices --- Matrices, Extracellular --- Cancer Microenvironment --- Cancer Microenvironments --- Microenvironment, Cancer --- Microenvironment, Tumor --- Microenvironments, Cancer --- Microenvironments, Tumor --- Tumor Microenvironments --- Extracellular matrix. --- Physiology, Pathological. --- Research. --- Cancer research --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Cement substance (Anatomy) --- Ground substance (Anatomy) --- Ground substance (Histology) --- Intercellular matrix --- Interstitial substance --- Connective tissues --- Extracellular space

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This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.

Cancer research. --- Molecular biology. --- Human genetics. --- Immunology. --- Human physiology. --- Cell biology. --- Cancer Research. --- Molecular Medicine. --- Human Genetics. --- Human Physiology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Human biology --- Medical sciences --- Physiology --- Human body --- Immunobiology --- Life sciences --- Serology --- Genetics --- Heredity, Human --- Physical anthropology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Cancer cells --- Growth. --- Tumors --- Tumor Microenvironment. --- Neoplasms --- Adaptation. --- Metabolism. --- metabolism. --- Cancer cell growth --- Cancer Microenvironment --- Cancer Microenvironments --- Microenvironment, Cancer --- Microenvironment, Tumor --- Microenvironments, Cancer --- Microenvironments, Tumor --- Tumor Microenvironments --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Adaptation (Physiology) --- Cancer. --- Medicine—Research. --- Biology—Research. --- Medical genetics. --- Cytology. --- Cancer Biology. --- Biomedical Research. --- Medical Genetics. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Genetic disorders --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Genetic aspects

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Neoplasms. --- Patient-Specific Modeling. --- Precision Medicine. --- Tumor Microenvironment. --- Theranostic Nanomedicine. --- Drug Resistance, Neoplasm. --- Antineoplastic Agent Resistance --- Neoplasm Drug Resistance --- Resistance, Antineoplastic Agent --- Resistance, Antineoplastic Drug --- Antibiotic Resistance, Neoplasm --- Antineoplastic Drug Resistance --- Drug Resistance, Antineoplastic --- Photothermal Theranostics --- Nanomedicine, Theranostic --- Nanomedicines, Theranostic --- Photothermal Theranostic --- Theranostic Nanomedicines --- Cancer Microenvironment --- Cancer Microenvironments --- Microenvironment, Cancer --- Microenvironment, Tumor --- Microenvironments, Cancer --- Microenvironments, Tumor --- Tumor Microenvironments --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Pharmacogenetics --- Patient-Specific Modeling --- Patient-Specific Computational Modeling --- Physiome --- Computational Modeling, Patient-Specific --- Modeling, Patient-Specific --- Patient Specific Computational Modeling --- Patient Specific Modeling --- Physiomes --- Models, Biological --- Precision Medicine --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Enginyeria biomèdica --- Resistència als medicaments --- Farmacoresistència --- Farmacologia --- Resistència a la insulina --- Efecte dels medicaments sobre els microorganismes --- Carcinomes --- Malalties neoplàstiques --- Neoplàsies --- Neoplasmes --- Patologia --- Càncer --- Feocromocitoma --- Fibromes --- Marcadors tumorals --- Mesotelioma --- Miomes --- Pòlips (Patologia) --- Sarcoïdosi --- Sarcoma --- Teratoma --- Tumors de parts toves --- Tumors en els animals --- Classificació de tumors --- Oncologia --- Quistos --- Enginyeria clínica --- Enginyeria mèdica --- Bioenginyeria --- Biofísica --- Enginyeria --- Medicina --- Electrònica mèdica --- Enginyeria de teixits --- Materials biomèdics --- Aparells i instruments mèdics --- Biomedical engineering. --- Research. --- Treatment. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cancer therapy --- Cancer treatment --- Cancer research --- Therapy