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This book offers an overview of the biological basis of 26 different solid cancers for scientists and oncologists to understand the clinical challenges. The book provides a quick, simplified, and updated review of the present genetic or genomic medicine era. With genetic and molecular details to enhance understanding of biological mechanisms underlying disease pathogenesis and treatment response, each chapter covers epidemiology, risk factors, classification, pathophysiology, genetics, and treatment of solid cancers. This book is a beginner’s guide for life sciences and medicine graduate students, fellows in training, biomedical sciences researchers, principal investigators, clinician-researchers and oncologists. .

Neoplasms. --- Neoplasms --- genetics. --- Oncology. --- Cancer. --- Tumors --- Cancers. --- Cancer Microenvironment. --- Cancer Staging. --- Classification.

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This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Cancer research. --- Cell biology. --- Internal medicine. --- Cancer Research. --- Cell Biology. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Cancer research --- Cancer --- Molecular aspects. --- Cancer. --- Cytology. --- Cancer Microenvironment. --- Cancer Biology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors

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This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.

Drug Resistance, Neoplasm. --- Immunotherapy. --- Tumor Microenvironment. --- Neoplasms --- drug therapy. --- Cancer. --- Cancer --- Cancer Biology. --- Cancer Microenvironment. --- Cancer Therapy. --- Treatment. --- Drug resistance --- Drug resistance in cancer cells. --- Chemotherapy. --- Neoplasm. --- Antineoplastic Agents --- Tumor Microenvironment --- Neoplastic Stem Cells --- drug effects.

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Engineering and Physical Approaches to Cancer addresses the newest research at this interface between cancer biology and the physical sciences. Several chapters address the mechanobiology of collective and individual cell migration, including experimental, theoretical, and computational perspectives. Other chapters consider the crosstalk of biological, chemical, and physical cues in the tumor microenvironment, including the role of senescence, polyploid giant cells, TGF-beta, metabolism, and immune cells. Further, chapters focus on circulating tumor cells and metastatic colonization, highlighting both bioengineered models as well as diagnostic technologies. Further, this book features the work of emerging and diverse investigators in this field, who have already made impressive cross-disciplinary scientific contributions. This book is designed for a general audience, particularly researchers conversant in cancer biology but less familiar with engineering (and vice-versa). Thus, we envision that this book will be suitable for faculty, postdoctoral fellows, and advanced graduate students across medicine, biological sciences, and engineering. We also anticipate this book will be of interest to medical professionals and trainees, as well as researchers in the pharmaceutical and biomedical device industry.

Cancer—Treatment. --- Cancer. --- Cancer—Imaging. --- Biomechanics. --- Cancer Therapy. --- Cancer Microenvironment. --- Cancer Imaging. --- Biological mechanics --- Mechanical properties of biological structures --- Biophysics --- Mechanics --- Contractility (Biology) --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Tumor Microenvironment. --- Neoplasms --- Extracellular Matrix. --- Biomechanical Phenomena. --- therapy. --- Biomechanic Phenomena --- Mechanobiological Phenomena --- Biomechanics --- Kinematics --- Biomechanic --- Biomechanic Phenomenas --- Phenomena, Biomechanic --- Phenomena, Biomechanical --- Phenomena, Mechanobiological --- Phenomenas, Biomechanic --- Physical and Rehabilitation Medicine --- Matrix, Extracellular --- Extracellular Matrices --- Matrices, Extracellular --- Cancer Microenvironment --- Cancer Microenvironments --- Microenvironment, Cancer --- Microenvironment, Tumor --- Microenvironments, Cancer --- Microenvironments, Tumor --- Tumor Microenvironments --- Cancer --- Imaging. --- Treatment. --- Cancer therapy --- Cancer treatment --- Imaging of cancer --- Therapy --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Benign Neoplasm --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology

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Lymphatic Metastasis. --- Neoplasm Metastasis. --- Tumor Microenvironment. --- Carcinogenesis. --- Oncogenesis --- Tumorigenesis --- Carcinogeneses --- Oncogeneses --- Tumorigeneses --- Cancer Microenvironment --- Cancer Microenvironments --- Microenvironment, Cancer --- Microenvironment, Tumor --- Microenvironments, Cancer --- Microenvironments, Tumor --- Tumor Microenvironments --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Metastase --- Metastasis --- Metastases --- Neoplasms --- Lymph Node Metastasis --- Lymph Node Metastases --- Lymphatic Metastases --- Metastasis, Lymph Node --- Sentinel Lymph Node --- Sentinel Lymph Node Biopsy --- secondary --- Lymphatics. --- Metastasis. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Lymphatic system --- Immune system --- Dissemination