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This volume is a practical guide of theranostics using intraoperative fluorescence imaging technology, as an all-out effort by the Japanese Society for Fluorescence Guided Surgery. It describes the various approaches the technique is being used such as vascular imaging, identification of lymphatic vessels by intratissue injection, lymph node imaging, and imaging for identification of anatomical structures. The book is organized into three major parts and the first one delivers the basics, introducing the use of the technology in clinical settings and initial setups. Next comes the description of clinical applications where chapters illustrate perfusion assessment, cancer localization, anatomy visualization, and lymph nodes/ducts mapping. Each chapter is devoted to the specific surgical field and disease areas, presenting images and videos of case studies. The last part presents some upcoming techniques for treatments. The Editor and the authors wish the ideas presented here will be hints to bridge the knowledge between surgeons and basic researchers for further innovation and practicality. It is important to stay up-to-date since intraoperative fluorescence imaging has been applied to clinical settings in various surgical fields and at the same time, novel techniques improving the efficacy of the technology have also been developed actively. Fluorescence-Guided Surgery – From Lab to Operation Room is recommended for surgeons, operating nurses, medical experts, basic researchers and, industry engineers worldwide beyond boundaries of specialties. Edited and written by experts of The Japanese Society for Fluorescence-Guided Surgery, those who are the founders of the technology, it describes the accurate development history and cutting-edge techniques based on the knowledge accumulated over the years. This is a translated version of the book originally published in Japanese language. This has been facilitated using machine translation (by the service DeepL.com) followed by authors revising, editing and verifying the translated manuscript.

Surgery. --- Endoscopic surgery. --- Cancer --- Oncology. --- Diseases. --- Anatomy. --- Minimally Invasive Surgery. --- Cancer Imaging. --- Imaging. --- Computer-assisted surgery.

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This book presents the rapidly developing field of artificial intelligence and machine learning and its application in biomedical imaging. As is known, starting from the diagnosis of fractures by using X-rays to understanding the complex structure and function of the brain, biomedical imaging has contributed immensely toward the development of precision diagnosis and treatment strategies for numerous diseases. While continuous evolution in imaging technologies have enabled the acquisition of images having resolution and contrast far better than ever, it significantly increased the volume of data associated with each image scan—making it increasingly difficult for experts to analyze and interpret. In this context, the application of artificial intelligence (AI) and machine learning (ML) tools has become one of the most exciting frontlines of contemporary research in biomedical imaging due to their capability to extract minute traces of various disease signatures from large and complicated datasets and providing clear insight into the potential abnormalities with excellent accuracy, sensitivity, and specificity. The hallmark of this book will be the contributions from international leaders on different AI-aided advanced biomedical imaging modalities and techniques. Included will be comprehensive description of several of the technology-driven spectacular advances made over the past few years that have allowed early detection and delineation of abnormalities with sub-pixel image segmentation and classification. Starting from the fundamentals of biomedical image processing, the book presents a streamlined and focused coverage of the core principles, theoretical and experimental approaches, and state-of-the-art applications of most of the currently used biomedical imaging techniques powered by AI.

Biophysics. --- Biomedical engineering. --- Optical spectroscopy. --- Cancer --- Bioanalysis and Bioimaging. --- Biomedical Engineering and Bioengineering. --- Optical Spectroscopy. --- Cancer Imaging. --- Imaging.

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Thepastdecadehasseendramaticadvances inurologyandimaging. Thesechangesareevident in improvements in laparoscopic surgery as well as in the emergence of multidetector CT, with multiplanar reformatting and FDG-PET-CT as routine imaging methods. The new minimally invasive procedures often require more exacting imaging as the surgeon does not have the same visual ?eld of view as was possible with open procedures. Thus, it is appropriate now to p- vide an update on imaging advances for the bene?t of urologists and radiologists alike. The increasing number of innovative imaging approaches to urologic tumors including CT, MRI, PET, SPECT, and endoscopic imaging can be perplexing and lead to over- and underesti- tions of the capabilities of modern imaging on the part of those who interpret them and those who use the information they provide for patient management. There is a growing “exp- tations gap” between what is expected and what is possible that needs to be closed. While previous books have focused on the more common urologic tumors such as bladder, prostate, andkidneycancer,nonehasattemptedacomprehensivereviewofthestateoftheartofimaging in most of the tumors involved in urologic oncology. Imaging in Urologic Oncology addresses these challenges. In the modern imaging department it is easy to forget how useful conventional plain rad- graphy can be in urologic diagnosis. Much of our current understanding of urologic disease is based on the “classic appearance” on intravenous urograms, cystograms, or retrograde pye- grams. Therefore, conventional imaging provides the ?rst “layer” in our understanding of u- logic tumors. The next layer is cross-sectional imaging.

Bladder -- Cancer -- Imaging. --- Kidneys -- Cancer -- Imaging. --- Prostate -- Cancer -- Imaging. --- Urogenital Neoplasms --- Diagnostic Imaging --- Male Urogenital Diseases --- Female Urogenital Diseases --- Diagnostic Techniques and Procedures --- Neoplasms by Site --- Diseases --- Neoplasms --- Diagnosis --- Female Urogenital Diseases and Pregnancy Complications --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Urology. --- Oncology. --- Medicine. --- Radiology. --- Medicine & Public Health. --- Imaging / Radiology. --- Tumors --- Genitourinary organs

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This book highlights the most efficient and latest ways to deal with cancer, focusing on IONPs. The book describes some well-designed surface modifications performed through several functional materials over the surface of IONPs, which results in the development of multifunctional IONPs-based delivery nanoplatforms by enhancing solubility, stability, and avoiding side effects on healthy cells. Several types of stimuli-responsive IONPs-based strategies are also discussed. Owing to magnetic, structural, and thermal properties, IONPs themselves can be utilized for magnetic targeting, magnetic hyperthermia, and phototherapy. Significant advancements are presented in IONPs-based immunotherapy, radiotherapy, and sonodynamic therapy for the efficient treatment of cancer. Finally, the book presents RIONs which serve as the parent platform for the development of powerful DMCAs utilized in SPECT/MRI and PET/MRI applications.

Medical physics. --- Cancer --- Nanochemistry. --- Nanotechnology. --- Biophysics. --- Medical Physics. --- Cancer Imaging. --- Nanoengineering. --- Bioanalysis and Bioimaging. --- Imaging. --- Nanoparticles. --- Treatment --- Technological innovations. --- Theranostic Nanomedicine. --- Neoplasms --- Magnetic Iron Oxide Nanoparticles. --- diagnostic imaging.

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This book presents a comprehensive set of methods for quantifying geometric quantities such as the volume of a tumor, the total surface area of the alveoli in a lung, the length of plant roots, or of blood vessels, the number of neurons in a brain compartment, the connectivity number of trabecular bone, the mean size of grains in a rock, etc.. The methods, illustrated by twenty solved case studies, are based on properly sampled slices, sections, or projections of the material, observable under light, laser, or electron microscopy, or under non-invasive radiological devices such as ecography, computed tomography, or magnetic resonance imaging. Thus, the input usually consists of flat images, and the output consists of relevant quantities defined in three dimensions. Stereology is the discipline of providing sampling designs which warrant unbiased estimation of the corresponding quantities, that is, estimation with zero mean deviation from the target. Sampling is usually systematic (i.e., with regularly spaced probes), and sparse (as opposed to reconstructions) and it is thereby efficient and easy to implement. Stereology is essentially geometric sampling, grounded on integral geometry. The necessary elements of both disciplines are detailed in textbook style, and may be used for postgraduate courses, or to serve the interest of scientists in general. Hitherto no other book on stereology has appeared which encompasses the theory, methodology, and applications of stereology in an interconnected and comprehensive way. The currently available error variance prediction formulae under systematic sampling, and their (non-obvious) derivation, are all gathered, for the first time, in the last chapter. The exposition is augmented by 127 line drawings for the theory, and 27 color pictures of real materials for the case studies.

Geometry. --- Image processing --- Computer vision. --- Anatomy. --- Radiology. --- Cancer --- Computer Imaging, Vision, Pattern Recognition and Graphics. --- Cancer Imaging. --- Digital techniques. --- Imaging. --- Stereology.