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« Par le biais d'une approche vulgarisée, ce livre présente les données scientifiques récentes permettant de comprendre la neurobiologie des douleurs à l'échelle de l'organisme, de la physiologie et de la physiopathologie, et à l'échelle cellulaire, des aspects moléculaires des systèmes intervenant dans la génèse et la modulation de l'information douloureuse. "Douleurs" car il y a plusieurs : douleur aiguë par excès de nociception, douleur chronique inflammatoire, douleur chronique neuropathique, douleurs mixtes du cancer, douleur du membre fantôme, douleurs idiopathiques nociplastiques. L'objectif de cet ouvrage est de faire comprendre la complexité de la douleur, en incistant sur celle, particulière, du passage de la douleur aiguë à la douleur chronique, principal problème rencontré par les cliniciens du fait de la grande difficulté à soulager. L'ouvrage décline les principaux apports de la recherche sur la douleur. Sont ainsi abordés aussi bien des thèmes d'introduction qui permettent au lecteur de saisir ce qu'est la douleur dans sa complexité, et d'autres, beaucoup plus spécifiques, comme la douleur du cancer, la mémoire de la douleur et les aspects moléculaires des systèmes endogènes opioïdes et cannabinoïdes. Peu de médecins sont formés pour la prise en charge de la douleur et il est donc important de pouvoir mettre à disposition un ouvrage scientifique qui permette de mieux l'appréhender. Il sera également très utile à tous les étudiants désireux d'approfondir leurs connaissances suivant les cursus des études de médecine et des différents diplômes associés à l'enseignement de la douleur (capacité, DU-DIU) mais aussi des études scientifiques de neurosciences. »-- Quatrième de couverture.

Bone metastasis. --- Canaux ioniques. --- Cancer Animal models.

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Carcinogenesis --- Congresses --- Cancer --- Risk factors --- Animal models --- Carcinogenesis - Congresses. --- Cancer - Risk factors - Congresses. --- Cancer - Animal models - Congresses. --- DISEASE MODELS, ANIMAL --- NEOPLASMS, EXPERIMENTAL --- RESEARCH --- CHEMICALLY INDUCED --- METHODS

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Energy Intake --- Dietary Fats --- Exercise --- Neoplasms --- Neoplasms, Experimental --- 613.2 --- Cancer --- -Cancer --- -Carcinogenesis --- -Exercise --- -Fat --- -Low-calorie diet --- -Caloric restriction --- Calorie-restricted diet --- Calorie restriction --- Diet, Low-calorie --- Reducing diets --- Fats --- Lipids --- Adipose tissues --- Physical activity --- Warm-up --- Workouts (Exercise) --- Health --- Physical education and training --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- physiology. --- adverse effects. --- etiology. --- chemically induced. --- Voedingsleer. Dieet --- Animal models --- -Congresses --- Nutrition aspects --- Congresses --- Physiological aspects --- Physiological effect --- Pathogenesis --- -physiology. --- Carcinogenesis --- Fat --- Low-calorie diet --- Caloric restriction --- Nutritional aspects --- adverse effects --- physiology --- chemically induced --- etiology --- Cancer - Nutrition aspects - Congresses. --- Fat - Physiological effect - Congresses. --- Exercise - Physiological aspects - Congresses. --- Low-calorie diet - Physiological aspects - Congresses. --- Carcinogenesis - Congresses. --- Cancer - Animal models - Congresses. --- CALORIC INTAKE --- DIETARY FATS --- EXERCISE --- NEOPLASMS --- NEOPLASM, EXPERIMENTAL --- PHYSIOLOGY --- ADVERSE EFFECTS --- ETIOLOGY --- CHEMICALLY INDUCED

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Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.

Cancer -- Animal models. --- Mice -- Genetic engineering. --- Mice as laboratory animals. --- Transgenic mice. --- Mice --- Transgenic mice --- Mice as laboratory animals --- Cancer --- Organism Forms --- Models, Biological --- Animal Population Groups --- Models, Animal --- Animal Diseases --- Animals, Genetically Modified --- Diseases --- Investigative Techniques --- Models, Theoretical --- Murinae --- Organisms --- Animals --- Eukaryota --- Muridae --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Rodentia --- Mammals --- Vertebrates --- Chordata --- Disease Models, Animal --- Mice, Transgenic --- Animals, Laboratory --- Organisms, Genetically Modified --- Medicine --- Biology --- Health & Biological Sciences --- Genetics --- Oncology --- Genetic engineering --- Animal models --- Animal models. --- Research. --- Cancer research --- Medicine. --- Cancer research. --- Human genetics. --- Laboratory medicine. --- Medical microbiology. --- Parasitology. --- Biochemistry. --- Biomedicine. --- Cancer Research. --- Human Genetics. --- Laboratory Medicine. --- Medical Microbiology. --- Animal Biochemistry. --- Transgenic animals --- Oncology. --- Medical laboratories. --- Microbiology. --- Medical parasitology. --- Human beings --- Human parasitology --- Medical sciences --- Parasitology --- Parasitic diseases --- Microbial biology --- Microorganisms --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Parasites --- Composition --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology