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Oncogenes --- Gene expression --- Antisense nucleic acids - Therapeutic use - Testing. --- Cancer - Genetic aspects. --- AIDS (Disease) - Genetic aspects. --- Oncogenes. --- Gene expression.

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Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.

Cancer. --- Cancer—Animal models. --- Cancer—Treatment. --- Cancer—Genetic aspects. --- Cancer Biology. --- Cancer Models. --- Cancer Therapy. --- Cancer Genetics and Genomics. --- Cancer Microenvironment. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors

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Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so

Cancer -- Genetic aspects. --- Cancer -- Molecular aspects. --- Cancer -- Treatment. --- Diseases --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Molecular aspects. --- Genetic aspects. --- Treatment. --- Cancer therapy --- Cancer treatment --- Cancer genetics --- Cancer genes --- Therapy

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More than 180 participants and experts from 31 countries met for the fifth time in 10 years in St. Gallen, Switzerland for a 3-day conference to discuss important current issues of clinical cancer prevention. The meeting was again organized and co-sponsored by St. Gallen Oncology Conferences (SONK). While SONK has been extremely successful in organizing large international c- gresses on “Primary Therapy of Early Breast Cancer” as well as “Supportive Care in Cancer” for more than 20 years, the idea of promoting interdisciplinary, clinically oriented meetings on cancer prevention is a more recent and not yet generally accepted and w- comed concept in modern oncology. Since today’s medical expenses are soaring and me- cal research budgets are stagnating or even being cut, neither politicians nor industry is willing to risk an additional unpredictable channel of expenses, such as that demanded by clinical cancer prevention efforts! In Switzerland—and we fear in many other parts of the globe—some 97%–98% or even a greater percentage of health budgets is spent for curative and palliative/rehabilitative m- icine. Since a meager 2%–3% of national health budgets is for preventive medicine, even less than that proportion is specifically allocated for cancer prevention. When the money for “curing and caring” for the diseased populace runs short, there is likely not much left for partly controversial disease prevention in the (still) healthy part of the population.

Cancer -- Genetic aspects -- Congresses. --- Cancer -- Genetic aspects. --- Cancer -- Prevention -- Congresses. --- Cancer -- Prevention. --- Chemoprevention -- Congresses. --- Neoplasms -- genetics -- Congresses. --- Cancer --- Biology --- Diseases --- Drug Therapy --- Publication Formats --- Therapeutics --- Biological Science Disciplines --- Publication Characteristics --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Genetics --- Congresses --- Chemoprevention --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Prevention --- Genetic aspects --- Medicine. --- Cancer research. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Tumors --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians

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The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

Molecular biology --- Oncology. Neoplasms --- moleculaire biologie --- kwaadaardige gezwellen --- Cancer --- Cancer cells. --- Cellules cancéreuses --- Molecular aspects. --- Genetic aspects. --- Aspect moléculaire --- Aspect génétique --- Cancer cells --- Neoplasms --- Genes, Neoplasm --- Cell Transformation, Neoplastic --- Molecular aspects --- Genetic aspects --- genetics --- Cell Transformation, Neoplastic. --- Genes, Neoplasm. --- genetics. --- Genetics. --- Cellules cancéreuses --- Aspect moléculaire --- Aspect génétique --- Monograph --- Cancer - Molecular aspects --- Cancer - Genetic aspects --- Neoplasms - genetics