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Camptothecin --- Cancer --- Derivatives --- Chemotherapy --- Congresses
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Camptothecin. --- Alkaloids --- Antineoplastic agents --- Antiviral agents
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Camptothecin --- Cancer --- Antineoplastic Agents --- Congresses. --- Chemotherapy --- Analogs & derivatives --- pharmacology --- congresses. --- therapeutic use --- Congresses --- Camptothecin - Congresses.
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Carboplatin --- Antineoplastic Agents --- Camptothecin --- Neoplasms --- pharmacokinetics --- administration & dosage --- adverse effects --- drug therapy
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NEOPLASMS --- ANTINEOPLASTIC AGENTS --- CAMPTOTHECIN --- PURINES --- DRUG RESISTANCE --- PLATINUM COMPOUNDS --- ANTIBIOTICS, ANTHRACYCLINE --- DRUG THERAPY --- ANALOGS AND DERIVATIVES --- ANALOGS AND DERIVATIVES --- NEOPLASMS --- ANTINEOPLASTIC AGENTS --- CAMPTOTHECIN --- PURINES --- DRUG RESISTANCE --- PLATINUM COMPOUNDS --- ANTIBIOTICS, ANTHRACYCLINE --- DRUG THERAPY --- ANALOGS AND DERIVATIVES --- ANALOGS AND DERIVATIVES
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Clinical interest in the camptothecins continues to expand even though this class of topoisomerase I inhibitors has been studied for almost 50 years, and two early generation members of the family have gained FDA approval. In Camptothecins in Cancer Therapy, leading clinicians and researchers critically review our current understanding of camptothecins, their shortcomings, and the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance. Authoritative and up-to-date, Camptothecins in Cancer Therapy provides a comprehensive summary of camptothecin research, as well as a much-needed guide to all the latest information on their optimal therapeutic applications.
Camptothecin --- Neoplasms --- Antineoplastic Agents, Phytogenic --- Camptothecin. --- Cancer --- therapeutic use. --- drug therapy. --- analogs & derivatives. --- pharmacology. --- Chemotherapy. --- Chimiothérapie --- Chemotherapy --- therapeutic use --- drug therapy --- analogs and derivatives --- pharmacology --- Cancer -- Chemotherapy. --- Alkaloids --- Diseases --- Therapeutics --- Antineoplastic Agents --- Biological Science Disciplines --- Therapeutic Uses --- Natural Science Disciplines --- Heterocyclic Compounds --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Pharmacology --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Antiviral agents --- Treatment --- Oncology . --- Cancer - Chemotherapy --- Camptothecin - therapeutic use --- Neoplasms - drug therapy --- Antineoplastic Agents, Phytogenic - therapeutic use --- Camptothecin - analogs and derivatives --- Camptothecin - pharmacology
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In the landscape of the design of carbon nanomaterials, the fine-tuning of their functionalities and physico-chemical properties has increased their potential for therapeutic, diagnostic, and biosensing applications. In this editorial, we will provide a brief overview of the contents of this Special Issue. In particular, nanoplatforms originating from the synergistic combination of carbon-based nanomaterials (i.e., nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) with various functional molecules such as drugs, natural compounds, biomolecules, polymers, metal nanoparticles, and macrocycles that have useful applications in drug delivery, multi-targeted therapies, theranostic as well as scaffolds in tissue engineering, and as sensing materials have been selected for publication as Articles or Mini Reviews. The variety of applications covered by the nine articles published in this Special Issue of Nanomaterials are proof of the growing attention that the use of carbon nanomaterials in the biomedical/pharmaceutical field has received in recent years. We hope that readers find the contents of this Special Issue useful for their research, which is aimed to advance carbon nanomaterials from the laboratory to clinical nanomedicine.
graphene oxide --- covalent functionalization --- cortical membranes --- calcium phosphate deposition --- graphene/gold nanocomposite --- SERS --- Dopamine --- Rhodamine 6G --- nanodiamond --- tritium --- biodistribution --- Ewing sarcoma --- drug delivery --- siRNA --- nanomedicine --- porphyrin --- J-aggregates --- carbon nanotubes --- nanohybrids --- graphene --- liquid biopsy --- circulating tumor cells --- exosomes --- circulating nucleic acids --- COVID-19 --- pyrrole --- cancer --- doxorubicin --- drug delivery systems --- nanoparticles --- carbon dots --- platelet aggregation --- arterial thrombosis --- signaling molecules --- bleeding disorder --- cytotoxicity --- carbon nanomaterials --- camptothecin --- Caco-2 --- MCF-7 --- NanoHy-GPS --- antibacterial nanosystems --- one-pot microwave-assisted reaction --- silver nanoparticles --- polyvinyl alcohol --- n/a
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Life in biological systems is maintained by the cooperative actions of various biomolecules. With the development of chemical and biological technologies related to nucleic acids, the details of the mechanisms of such cooperative actions between nucleic acids and other biomolecules have been elucidated and further applied in various applications. In the papers published in this Special Issue, advanced research works involved in nucleic acid conjugates are reported in wide application fields, such as artificial gene regulation, biomolecular sensing, and therapeutics from leading scientists in nucleic acids chemistry and engineering.
Technology: general issues --- fluorescent probe --- conjugate --- abasic site --- DNA --- microRNA --- RNA binding protein --- PUF --- RNA regulation --- DNA-protein conjugate --- replication initiation protein --- DNA aptamer --- BRET-based biosensor --- oligonucleotide --- crosslink --- nucleic acid binding protein --- cytosine methyltransferase --- mRNA --- poly(A) tail --- artificial viral capsid --- encapsulation --- nanocapsule --- self-assembly --- β-annulus peptide --- peptide-DNA conjugate --- PNA --- invasion --- NLS --- drug delivery system --- anticancer drug --- camptothecin derivative --- irinotecan --- ribonucleopeptide (RNP) --- RNA-peptide conjugate --- Schiff base --- aptamer --- fluorescent sensors --- therapeutic nucleic acid --- drug delivery --- nanoparticles --- cytotoxicity --- macrophages --- cellular uptake --- small interfering RNA --- multiple sclerosis --- repulsive guidance molecule a --- catalytic RNA --- group I ribozyme --- RNA nanostructure --- RNA nanotechnology --- RNA-protein complex --- trans-splicing --- n/a
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In the landscape of the design of carbon nanomaterials, the fine-tuning of their functionalities and physico-chemical properties has increased their potential for therapeutic, diagnostic, and biosensing applications. In this editorial, we will provide a brief overview of the contents of this Special Issue. In particular, nanoplatforms originating from the synergistic combination of carbon-based nanomaterials (i.e., nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) with various functional molecules such as drugs, natural compounds, biomolecules, polymers, metal nanoparticles, and macrocycles that have useful applications in drug delivery, multi-targeted therapies, theranostic as well as scaffolds in tissue engineering, and as sensing materials have been selected for publication as Articles or Mini Reviews. The variety of applications covered by the nine articles published in this Special Issue of Nanomaterials are proof of the growing attention that the use of carbon nanomaterials in the biomedical/pharmaceutical field has received in recent years. We hope that readers find the contents of this Special Issue useful for their research, which is aimed to advance carbon nanomaterials from the laboratory to clinical nanomedicine.
Technology: general issues --- Chemical engineering --- graphene oxide --- covalent functionalization --- cortical membranes --- calcium phosphate deposition --- graphene/gold nanocomposite --- SERS --- Dopamine --- Rhodamine 6G --- nanodiamond --- tritium --- biodistribution --- Ewing sarcoma --- drug delivery --- siRNA --- nanomedicine --- porphyrin --- J-aggregates --- carbon nanotubes --- nanohybrids --- graphene --- liquid biopsy --- circulating tumor cells --- exosomes --- circulating nucleic acids --- COVID-19 --- pyrrole --- cancer --- doxorubicin --- drug delivery systems --- nanoparticles --- carbon dots --- platelet aggregation --- arterial thrombosis --- signaling molecules --- bleeding disorder --- cytotoxicity --- carbon nanomaterials --- camptothecin --- Caco-2 --- MCF-7 --- NanoHy-GPS --- antibacterial nanosystems --- one-pot microwave-assisted reaction --- silver nanoparticles --- polyvinyl alcohol --- n/a
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