Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Energy Intake --- Dietary Fats --- Exercise --- Neoplasms --- Neoplasms, Experimental --- 613.2 --- Cancer --- -Cancer --- -Carcinogenesis --- -Exercise --- -Fat --- -Low-calorie diet --- -Caloric restriction --- Calorie-restricted diet --- Calorie restriction --- Diet, Low-calorie --- Reducing diets --- Fats --- Lipids --- Adipose tissues --- Physical activity --- Warm-up --- Workouts (Exercise) --- Health --- Physical education and training --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- physiology. --- adverse effects. --- etiology. --- chemically induced. --- Voedingsleer. Dieet --- Animal models --- -Congresses --- Nutrition aspects --- Congresses --- Physiological aspects --- Physiological effect --- Pathogenesis --- -physiology. --- Carcinogenesis --- Fat --- Low-calorie diet --- Caloric restriction --- Nutritional aspects --- adverse effects --- physiology --- chemically induced --- etiology --- Cancer - Nutrition aspects - Congresses. --- Fat - Physiological effect - Congresses. --- Exercise - Physiological aspects - Congresses. --- Low-calorie diet - Physiological aspects - Congresses. --- Carcinogenesis - Congresses. --- Cancer - Animal models - Congresses. --- CALORIC INTAKE --- DIETARY FATS --- EXERCISE --- NEOPLASMS --- NEOPLASM, EXPERIMENTAL --- PHYSIOLOGY --- ADVERSE EFFECTS --- ETIOLOGY --- CHEMICALLY INDUCED

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

Research & information: general --- Biology, life sciences --- Food & society --- calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte --- calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In recent years, great attention has been paid to polyphenols due to their positive effects on health. One of the most widely-studied phenolic compounds is resveratrol. This molecule, which is naturally present in some foods, shows beneficial effects on various physiological and biochemical processes, thus representing a potential tool for the prevention or the treatment of diseases highly prevalent in our society. Several of these beneficial effects have been observed in human beings, but others only in pre-clinical studies so far, and therefore, it is mandatory to continue with the scientific research in this field. Indeed, new knowledge concerning these issues could enable the development of novel functional foods or nutraceuticals, incorporating resveratrol, suitable for preventing or treating diseases such as cancer, cardiovascular diseases, obesity, dislipemia, insulin resistance and diabetes, liver diseases, etc.

polyphenols --- ?-viniferin --- leptin resistance --- p53 --- kidney --- energy restriction --- grape powder extract --- cytokines --- phosphorylation --- obesity --- energy metabolism --- metabolic pathways --- endothelial function --- polyol pathway --- antioxidant --- caloric restriction --- rat --- adipose tissue --- microparticles --- pathways --- angiotensin converting enzyme 2 --- resistance --- esRAGE --- interleukins --- metabolic syndrome --- dissolution rate --- thermogenesis --- streptozotocin --- bioavailability --- solubility --- metabolism --- renin-angiotensin system --- microbiota --- Sirt-1 --- magnesium dihydroxide --- hypertrophy --- metabolic diseases --- physiological adaption --- red wine extract --- lens --- distribution --- MTA1 --- sirtuin --- inflammation --- cardiac function --- rats --- cisplatin --- resveratrol --- mitochondria --- breast cancer --- ischemia-reperfusion --- cardiovascular --- metabolites --- gut microbiota --- prostate cancer --- performance --- type 2 diabetes --- cafeteria diet --- high-fat high-sucrose diet --- resistance exercise --- aging --- diabetes --- oxidative stress

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

Research & information: general --- Biology, life sciences --- Food & society --- calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The kidney performs important functions in the human body and can inflict either acute kidney injury (AKI) or chronic kidney disease (CKD). AKI can be induced by kidney ischemia, drugs such as cisplatin, and heavy metals such as cadmium and arsenic. CKD can be induced by drugs, heavy metals, hypertension, and diabetes, as well as cancer. Importantly, nearly all kidney disorders have been shown to involve redox imbalance, reductive stress, oxidative stress, and mitochondrial abnormalities such as impaired mitochondrial homeostasis, including disrupted mitophagy and deranged mitochondrial unfolded protein responses. Understanding how these redox-related dysregulated pathways operate may give us new insights into how to design novel approaches to fighting kidney disease. This Special Issue of Biomolecules entitled “Redox imbalance and mitochondrial abnormalities in kidney disease” covers a variety of topics focusing on oxidative stress, mitochondrial dysfunction, and antioxidation enhancement implicated in kidney disease or kidney transplantation.

diabetic kidney disease --- caloric restriction --- NADH/NAD+ --- redox imbalance --- mitochondrial homeostasis --- mitophagy --- oxidative stress --- kidney allograft --- kidney rejection --- ischemia --- acute kidney injury (AKI) --- chronic kidney disease (CKD) --- tricarboxylic acid (TCA) cycle --- mitochondrial metabolism --- mitochondrial redox signaling --- mitochondrial proteins --- oxidative phosphorylation (OXPHOS) --- fatty acid (FA) β-oxidation --- mitochondrial dynamics --- biogenesis --- diabetes --- kidney --- mitochondria --- Oryza sativa --- rice husk --- TCA cycle metabolites --- kidney diseases --- renalase --- chronic kidney disease --- major adverse cardiovascular outcomes --- cadmium --- kidney injury --- renal toxicity --- oxidative damage --- proximal tubule --- controlled oxygenated rewarming --- mitochondrial uncoupling --- rewarming injury --- temperature paradox --- redox --- mitochondrial dysfunction --- SGLT2 --- mitochondrial reactive oxygen species --- Warburg effect --- podocytopathies --- mitochondrial oxidative stress --- reactive oxygen species (ROS) --- antioxidant defense --- cell death --- n/a