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Physiology of nerves and sense organs --- Calcium channels --- Calciumkanalen --- Circuits du calcium --- Nerve-cells --- Neurocyte --- Neuronen --- Neurones --- Neurons --- Calcium channels. --- Calcium --- Neurons. --- Calcium Channels --- Physiological effect. --- physiology. --- pharmacology. --- Physiological effect --- Calcium - Physiological effect.

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CALCIUM, physiology --- drug effects --- Cellular control mechanisms --- Intracellular calcium --- Cellular calcium --- Calcium in the body --- Second messengers (Biochemistry) --- Cell regulation --- Biological control systems --- Cell metabolism --- Physiological effect --- General biochemistry --- Molecular biology --- Calcium --- Cells --- metabolism --- Calcium - Physiological effect --- Cells - drug effects --- Calcium - metabolism

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Calcium --- Calcium channel blockers. --- Cardiovascular Diseases. --- Heart --- Metabolism. --- Antagonists --- Therapeutic use. --- Diseases --- Chemotherapy. --- Physiological effect. --- Antagonistes --- Emploi en thérapeutique --- Effets physiologiques --- Cardiovascular Diseases --- Calcium Channel Blockers --- metabolism --- Therapeutic use --- Chemotherapy --- Physiological effect --- Emploi en thérapeutique --- Calcium Channel Blockers. --- metabolism. --- Cardiopulmonary system --- Cardiovascular system --- Chest --- Alkaline earth metals --- High-calcium diet --- Antagonists&delete& --- Diseases&delete& --- Cardiovascular agents --- Calcium - metabolism --- Calcium - Antagonists - Therapeutic use --- Heart - Diseases - Chemotherapy --- Calcium - Physiological effect --- CARDIO-VASCULAIRE, APPAREIL --- CALCIUM --- CALCIUM CHANNEL BLOCKERS --- MALADIES --- ANTAGONISTS AND INHIBITORS

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Calcium is crucial in governing contractile activities of myofilaments in cardiomyocytes, any defeats in calcium homeostasis of the cells would adversely affect heart pumping action. The characterization of calcium handling properties in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMCs) is of significant interest and pertinent to the stem cell and cardiac regenerative field because of their potential patient-specific therapeutic use.

Calcium -- Physiological effect. --- Cardiology. --- Cytology. --- Heart cells. --- Stem cells. --- Heart cells --- Stem cells --- Calcium --- Blood Coagulation Factors --- Metals, Alkaline Earth --- Myocardium --- Adult Stem Cells --- Metabolic Phenomena --- Muscle Cells --- Pluripotent Stem Cells --- Biological Factors --- Phenomena and Processes --- Stem Cells --- Elements --- Heart --- Muscle, Striated --- Metals --- Cells --- Inorganic Chemicals --- Cardiovascular System --- Chemicals and Drugs --- Anatomy --- Muscles --- Tissues --- Induced Pluripotent Stem Cells --- Myocytes, Cardiac --- Metabolism --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Cytology --- Physiological effect --- Metabolism. --- Cardiac cells --- Cardiocytes --- Cardiomyocytes --- Calcium metabolism --- Life sciences. --- Cell biology. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cell biology --- Cellular biology --- Cytologists --- Internal medicine --- Biosciences --- Sciences, Life --- Science --- Diseases

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This book brings together leading international experts to discuss recent advances in the regulation of presynaptic voltage-gated Ca2+ channels (VGCCs), key signal transducers that represent one of the most widely modulated proteins in the body. It is now commonly accepted that presence of the VGCC complex defines an excitable cell. At a basic level, VGCCs transduce membrane potential change to chemical neurotransmitter release at presynaptic terminals. However, on-going scientific research, presented here, in areas including neuroscience, electrophysiology, pharmacology, biochemistry and, increasingly, proteomics, has revealed the widespread nature of modulation of the presynaptic VGCC complex. This book reviews and discusses the following topics: The fundamental role of the VGCC pore-forming CaVa subunit, and some of their binding partners, in presynaptic function and synaptic plasticity. Modulation of presynaptic CaVa subunits by auxiliary CaVb and a2d subunits and by their major interaction partners, such as active zone scaffolding proteins, synaptic proteins, G proteins and small GTPases, which, together, contribute to the VGCC proteome. Work at the cutting edge of research, including how direct electrophysiology recordings from presynaptic terminals and introduction of synthetic CaVa peptides into presynaptic terminals has expanded our knowledge of VGCC function. Evidence emerging over the last decade demonstrating that VGCC subunits represent bona fide molecular targets for therapeutic drug discovery. This development is illustrated by the introduction of the CaV2.2 blocker ziconotide, which represents an important proof-of-concept, but is best exemplified by the emergence of gabapentinoids, which bind the VGCC auxiliary a2d subunit, as first-line treatments for chronic neuropathic pain. Throughout, chapters are accompanied with illustrative Tables and Figure providing a useful and comprehensive summary of the current state-of-play in this area of significant therapeutic interest. Work described here also provides a solid basis for future research in this important area.

Calcium -- Physiological effect. --- Calcium channels. --- Calcium. --- Presynaptic receptors. --- Ion Channels --- Electrophysiological Processes --- Nervous System Physiological Processes --- Intercellular Junctions --- Axons --- Signal Transduction --- Nervous System --- Physiological Processes --- Membrane Glycoproteins --- Biochemical Processes --- Membrane Transport Proteins --- Nervous System Physiological Phenomena --- Cell Physiological Processes --- Electrophysiological Phenomena --- Neurons --- Nerve Fibers --- Cell Membrane Structures --- Anatomy --- Cell Membrane --- Biochemical Phenomena --- Membrane Proteins --- Physiological Phenomena --- Carrier Proteins --- Cells --- Musculoskeletal and Neural Physiological Phenomena --- Chemical Processes --- Cell Physiological Phenomena --- Proteins --- Chemical Phenomena --- Phenomena and Processes --- Cellular Structures --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Neuronal Plasticity --- Synaptic Transmission --- Synapses --- Presynaptic Terminals --- Calcium Channels --- Calcium in the body. --- Channels, Calcium --- Medicine. --- Cell physiology. --- Cell membranes. --- Neurobiology. --- Biomedicine. --- Biomedicine general. --- Membrane Biology. --- Cell Physiology. --- Body composition --- Calcification --- Ion channels --- Cell function --- Cytology --- Physiology --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Neurosciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce --- Cell membranes .