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Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.

Research & information: general --- Biology, life sciences --- Fabry disease --- human embryonic stem cells --- CRISPR/Cas9 genomic editing --- Mass spectrometry proteomic analysis --- hypertrophic cardiomyopathy --- disease model --- physical exercise --- cardiac cellular regeneration --- microRNA (miR) --- Akt signaling --- cardiomyocyte proliferation --- cardiac hypertrophy --- cardioprotection --- myocarditis --- inflammation --- leukocytes --- cardiomyocytes --- multi-electrode-array --- micro-electrode-array --- MEA --- drug/toxicity screening --- field potential --- arrhythmia --- electrocardiography --- cardiac regeneration --- stem cells --- iPSC --- PSC --- ESC --- cardiovascular disease --- regeneration --- cardiac progenitor cells --- induced pluripotent stem cells --- transdifferentiation --- direct reprogramming --- genetic engineering --- cardiac tissue engineering --- biomaterials --- 18F-FDG PET --- cardiac induced cells --- cardiac function --- non-invasive imaging --- human pluripotent stem cell --- ventricular --- maturation --- bone marrow stem cells --- angiogenesis --- myocardial infarction --- human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) --- iPS cells --- big conductance calcium activated potassium channel (BK) --- Maxi-K --- slo1 --- KCa1.1 --- iberiotoxin --- long QT syndrome --- mesenchymal stromal cells (MSC) --- mRNA --- miRNA --- cardiac reprogramming --- cardiac differentiation --- cardiovascular diseases --- adult stem cells --- myocardial infraction --- 3D printing --- 3D model --- bioprinting --- cardiovascular medicine --- heart --- myocardium --- heart valves --- vascular graft --- endothelialization --- tissue engineering --- decorin --- fibronectin --- electrospinning --- endothelial progenitor cells --- bioreactor --- biostable polyurethane --- MicroRNA --- Mir-133 --- coronary heart disease --- biomarker --- meta-analysis --- Fabry disease --- human embryonic stem cells --- CRISPR/Cas9 genomic editing --- Mass spectrometry proteomic analysis --- hypertrophic cardiomyopathy --- disease model --- physical exercise --- cardiac cellular regeneration --- microRNA (miR) --- Akt signaling --- cardiomyocyte proliferation --- cardiac hypertrophy --- cardioprotection --- myocarditis --- inflammation --- leukocytes --- cardiomyocytes --- multi-electrode-array --- micro-electrode-array --- MEA --- drug/toxicity screening --- field potential --- arrhythmia --- electrocardiography --- cardiac regeneration --- stem cells --- iPSC --- PSC --- ESC --- cardiovascular disease --- regeneration --- cardiac progenitor cells --- induced pluripotent stem cells --- transdifferentiation --- direct reprogramming --- genetic engineering --- cardiac tissue engineering --- biomaterials --- 18F-FDG PET --- cardiac induced cells --- cardiac function --- non-invasive imaging --- human pluripotent stem cell --- ventricular --- maturation --- bone marrow stem cells --- angiogenesis --- myocardial infarction --- human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) --- iPS cells --- big conductance calcium activated potassium channel (BK) --- Maxi-K --- slo1 --- KCa1.1 --- iberiotoxin --- long QT syndrome --- mesenchymal stromal cells (MSC) --- mRNA --- miRNA --- cardiac reprogramming --- cardiac differentiation --- cardiovascular diseases --- adult stem cells --- myocardial infraction --- 3D printing --- 3D model --- bioprinting --- cardiovascular medicine --- heart --- myocardium --- heart valves --- vascular graft --- endothelialization --- tissue engineering --- decorin --- fibronectin --- electrospinning --- endothelial progenitor cells --- bioreactor --- biostable polyurethane --- MicroRNA --- Mir-133 --- coronary heart disease --- biomarker --- meta-analysis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.

Fabry disease --- human embryonic stem cells --- CRISPR/Cas9 genomic editing --- Mass spectrometry proteomic analysis --- hypertrophic cardiomyopathy --- disease model --- physical exercise --- cardiac cellular regeneration --- microRNA (miR) --- Akt signaling --- cardiomyocyte proliferation --- cardiac hypertrophy --- cardioprotection --- myocarditis --- inflammation --- leukocytes --- cardiomyocytes --- multi-electrode-array --- micro-electrode-array --- MEA --- drug/toxicity screening --- field potential --- arrhythmia --- electrocardiography --- cardiac regeneration --- stem cells --- iPSC --- PSC --- ESC --- cardiovascular disease --- regeneration --- cardiac progenitor cells --- induced pluripotent stem cells --- transdifferentiation --- direct reprogramming --- genetic engineering --- cardiac tissue engineering --- biomaterials --- 18F-FDG PET --- cardiac induced cells --- cardiac function --- non-invasive imaging --- human pluripotent stem cell --- ventricular --- maturation --- bone marrow stem cells --- angiogenesis --- myocardial infarction --- human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) --- iPS cells --- big conductance calcium activated potassium channel (BK) --- Maxi-K --- slo1 --- KCa1.1 --- iberiotoxin --- long QT syndrome --- mesenchymal stromal cells (MSC) --- mRNA --- miRNA --- cardiac reprogramming --- cardiac differentiation --- cardiovascular diseases --- adult stem cells --- myocardial infraction --- 3D printing --- 3D model --- bioprinting --- cardiovascular medicine --- heart --- myocardium --- heart valves --- vascular graft --- endothelialization --- tissue engineering --- decorin --- fibronectin --- electrospinning --- endothelial progenitor cells --- bioreactor --- biostable polyurethane --- MicroRNA --- Mir-133 --- coronary heart disease --- biomarker --- meta-analysis