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Growth --- Growth --- plants --- plants --- Produit agrochimique. --- Foliar application --- Foliar application --- leaves --- leaves --- Spraying --- Spraying --- methods --- methods --- Nutrient transport --- Nutrient transport --- methodology --- methodology --- Translocation --- Translocation --- Crc --- Crc

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Perte au stockage --- Storage losses --- Aptitude à la conservation --- Blood-vessels. --- Fruit. --- Vascular endothelium. --- Vegetables. --- Endothelium --- Processing. --- Storage. --- Postharvest Treatment --- Postharvest Treatment. --- Canned vegetables --- Canned fruits --- Fruit products --- Fruit --- Hemostasis. --- Thrombosis --- Vegetables --- Blood Vessels --- Plant and Crop Sciences. Crop Sciences --- Etiology. --- physiopathology. --- blood. --- Crop Husbandry --- Nutritive value --- Keeping quality --- Drying --- postharvest technology --- Food technology --- Fruits --- storage --- Packaging --- Conservation --- Crc

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The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC.

colorectal cancer --- organoids --- 3D bioprinting --- patient-derived xenograft --- cancer-on-chip --- drug combination --- cancer stem cells --- drug resistance --- clinical trials --- tumor-initiating cells --- tumor heterogeneity --- patient-derived cancer models --- single-cell RNA-sequencing --- tumor metabolism --- transcriptional programs --- tumor cell differentiation --- immunotherapy --- methods --- chromosomal instability --- DNA damage --- targeted therapy --- decitabine --- colon cancer --- DNA methylation --- clinical translation study --- machine learning --- patient-derived tumor organoid --- precision medicine --- radiation response --- rectal cancer --- PDX model --- CRC --- mutation analysis --- histological examination --- animal models --- in vitro culture --- cancer stem cell methods --- SATB2 --- colorectal carcinoma --- prognosis --- CDX2 --- circulating tumor cells --- CTC cluster --- size-based method --- ScreenCell® --- epithelial mesenchymal transition --- hypoxia --- HIF-1α --- immunofluorescence analysis --- sequential filtration

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This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment

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This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment