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This dissertation by Mattias Törnudd investigates the effects of protamine on platelet function and coagulation in cardiac surgery, specifically focusing on the use of cardiopulmonary bypass (CPB). The research examines how protamine, used to reverse heparin's anticoagulant effects post-surgery, impacts platelet activity and coagulation. It explores dosing strategies to minimize the negative effects of protamine and reduce the risk of residual heparin. The study also evaluates differences in platelet function between venous and arterial blood. Aimed at medical professionals and researchers, the work contributes to the understanding of hemostatic challenges in cardiac surgery and offers insights into managing coagulation effectively.

Coagulation. --- Heparin. --- Coagulation --- Heparin

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Blood --- Coagulation.

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Blood Coagulation

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Blood coagulation factors. --- Blood --- Coagulation.

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Blood --- Erythrocytes --- Erythrocytes. --- Coagulation --- Coagulation.