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Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

high-fat high-carbohydrate diet --- toxicity --- oxysterol --- n/a --- squalene cyclase --- sterol content --- sterolomics --- Polystichum --- Smith-Lemli-Opitz syndrome --- antifungals --- alkaloid --- cycloartenol synthase --- degeneration --- phytosterol --- Rhizopus arrhizus --- fibroblasts --- pod-blast --- fern --- cholesterol --- cytotoxic activity --- N-methylpiperidine. reductive deamination --- genetic disease --- isoprenoid --- steroid --- atherosclerosis --- granatane --- antioxidant --- wound healing --- development --- enzyme-assisted derivatization --- maturity --- terpene --- keratinocytes --- C4-demethylation complex (C4DMC) --- ?-sitosterol --- mesocarp --- sterol biosynthesis --- mechanism-based inactivators --- Mucorales --- gas chromatography-mass spectrometry (GC-MS) --- Girard reagent --- ROS --- sterol pattern --- N-methylcadaverine --- ?-tocopherol --- electrospray ionization-mass spectrometry --- human African trypanosomiasis --- HUVECs --- lipidomics --- campesterol --- triterpene --- oxyphytosterol --- leishmania --- Chagas disease --- LOX-1 --- sterol C24-methyltransferase --- antifungal effectivity --- ergosterol biosynthesis --- hormone --- glucose homeostasis --- retina --- solanaceae --- cholestanoic acid --- algal sterols --- cell migration --- withanolides --- insulin resistance --- Zingiber officinale --- posaconazole --- synthesis --- pre-diabetes --- pharmacognosy --- sterol --- 4-methylsterol --- oleanolic acid --- antiparasitic drugs --- lupeol --- oilseed --- aurelianolides --- divalent metal co-factor ligation --- bile alcohol --- phytosterols --- azoles --- infectious disease --- gingerols --- UV-radiation --- oil bodies --- ZnO --- sterol 14?-demethylase --- stigmasterol