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This new textbook on bacterial physiology is aimed at senior level students pursuing a one-semester course in the biology or microbiology curriculum. The text takes a balanced view of prokaryotic physiology, discussing both bioenergetics and bacterial metabolism in a way that establishes general principles and concepts and emphasizes throughout the information gained from model systems. The book also covers some experimental design issues, giving students an appreciation of the practical aspects and consequences of bacterial metabolism. It also stimulates students’ interests in future developments in the field by including discussions by five world-famous bacterial physiologists about future developments in the field.

Prokaryotes. --- Monera --- Procaryotae --- Procaryotes --- Prokaryonta --- Prokaryotae --- Prokaryotic protists --- Microorganisms --- Bacteriology. --- Microbiology. --- Biochemistry. --- Cytology. --- Biochemistry, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Microbial biology --- Microbiology --- Composition --- Cell biology. --- Cèl·lules --- Fisiologia cel·lular --- Fisiologia --- Motilitat cel·lular --- Biologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules canceroses --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia)

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This volume explores the techniques used to study human and animal pericytes. Chapters in this volume cover a range of topics such as pericyte dissociation from tissues, and analysis by immunohistochemistry and flow cytometry; avian chimaeras to investigate the embryonic development of cell lineage; pericyte purification by fluorescence activated cell sorting and ensuing culture; tissue turnover and regeneration; and the dynamic study of pericyte involvement in cancer dissemination, in situ, and in culture. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Pericytes: Methods and Protocols is a valuable resource that helps researchers define the biologic identity, functions, and potentials of a cell lineage of increasing interest and therapeutic significance. .

Cèl·lules --- Sistema cardiovascular --- Aparell cardiovascular --- Aparell circulatori --- Sistema circulatori --- Sistema vascular --- Artèries --- Cor --- Sistema vasomotor --- Vasos sanguinis --- Circulació sanguínia --- Biologia --- Fisiologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules canceroses --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia) --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Biologia cel·lular --- Citogenètica --- Citoquímica --- Migració cel·lular --- Cèl·lules animals

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Liver --- Biliary tract --- Pancreas --- Liver Diseases. --- Pancreatic Diseases. --- Biliary Tract Diseases. --- Diseases --- Diseases. --- Gastroenterology. --- Hepatology. --- Bilious diseases and biliousness --- Hepatology --- Biliary Tract Disease --- Disease, Biliary Tract --- Diseases, Biliary Tract --- Tract Disease, Biliary --- Tract Diseases, Biliary --- Disease, Pancreatic --- Diseases, Pancreatic --- Pancreatic Disease --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Biliary tree --- Liver Diseases --- Pancreatic Diseases --- Biliary Tract Diseases --- Gastroenterology --- Digestive organs --- Endocrine glands --- Exocrine glands --- Bile --- Abdomen --- Pàncrees. --- Fetge. --- Bilis. --- Gastroenterologia. --- Malalties del pàncrees. --- Malalties del fetge. --- Hepatopaties --- Malalties hepàtiques --- Hepatologia --- Cirrosi hepàtica --- Hepatitis --- Hepatitis B --- Hepatitis vírica --- Hepatopaties alcohòliques --- Insuficiència hepàtica --- Síndrome de Budd-Chiari --- Fibrosi quística --- Hipoglucèmia --- Pancreatitis --- Medicina interna --- Aparell digestiu --- Gastroenterologia pediàtrica --- Proctologia --- Tracte gastrointestinal --- Malalties de l'aparell digestiu --- Fel --- Digestió --- Humors corporals --- Àcids biliars --- Pigments biliars --- Fetge --- Tracte biliar --- Cèl·lules hepàtiques --- Bilis --- Cirurgia hepàtica --- Illots de Langerhans

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This book introduces a fresh perspective on the conditions for the genesis of the first cell. An important possible environment of the prehistoric Earth has long been overlooked as a host to the perfect biochemical conditions for this process. The first complexes of continental crust on the early Earth must have already contained systems of interconnected cracks and cavities, which were filled with volatiles like water, carbon dioxide and nitrogen. This book offers insights into how these conditions may have provided the ideal physical and chemical setting for the formation of protocells and early stages of life. The authors support their hypothesis with a number of astonishing findings from laboratory experiments focusing on a variety of organic compounds, and on the formation of key cellular ingredients and of primitive cell-like structures. Moreover, they discuss the principles of prebiotic evolution regarding the aspects of order and complexity. Guiding readers through various stages of hypotheses and re-created evolutionary processes, the book is enriched with personal remarks and experiences throughout, reflecting the authors' personal quest to solve the mystery surrounding the first cell.

Life --- Origin. --- Abiogenesis --- Biogenesis --- Germ theory --- Heterogenesis --- Life, Origin of --- Life (Biology) --- Origin of life --- Plasmogeny --- Plasmogony --- Evolution (Biology) --- Exobiology --- Spontaneous generation --- Origin --- Biochemistry. --- Life sciences. --- Geology. --- Cell physiology. --- Biochemistry, general. --- Popular Life Sciences. --- Cell Physiology. --- Cell function --- Cytology --- Physiology --- Geognosy --- Geoscience --- Earth sciences --- Natural history --- Biosciences --- Sciences, Life --- Science --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Ciències de la vida --- Cèl·lules --- Biologia --- Fisiologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules canceroses --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia) --- Ciència --- Agricultura --- Botànica --- Ciències de la salut --- Zoologia

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Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Cancer research. --- Oncology  . --- Molecular biology. --- Cancer Research. --- Oncology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Tumors --- Cancer research --- Proteolytic enzymes --- Peptide hydrolases --- Proteases --- Hydrolases --- Physiological effect. --- Peptide Hydrolases --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Esteroproteases --- Peptidases --- Proteinases --- Proteolytic Enzymes --- Gene Products, pol --- Enzims --- Cèl·lules --- Càncer --- Carcinoma --- Carcinosi --- Càncer d'ossos --- Càncer de cap --- Càncer de coll --- Càncer de bufeta --- Càncer de fetge --- Càncer de laringe --- Càncer de mama --- Càncer de pàncrees --- Càncer de pell --- Càncer de pròstata --- Càncer de pulmó --- Càncer de ronyó --- Càncer de tiroide --- Càncer d'ovari --- Càncer gastrointestinal --- Càncer ginecològic --- Càncer en els adolescents --- Càncer en els infants --- Medicaments antineoplàstics --- Melanoma --- Leucèmia --- Sarcoma --- Carcinògens --- Cèl·lules canceroses --- Cirurgia oncològica --- Infermeria oncològica --- Malalts de càncer --- Metàstasi --- Oncologia --- Biologia --- Fisiologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia) --- Biocatalitzadors --- Ferments --- Catalitzadors --- Proteïnes --- Coenzims --- Enzims al·lostèrics --- Enzims microbians --- Fibrinolítics --- Hidrolases --- Iduronat-2-sulfatasa --- Inducció enzimàtica --- Isoenzims --- Malt --- Metal·loenzims --- Oxidoreductases --- Transferases --- Biocatàlisi --- Fermentació