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This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease’s manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.
Cancer --- Genetic aspects. --- Cancer genetics --- Cancer genes --- Oncology . --- Rectum—Surgery . --- Gastroenterology . --- Oncology. --- Colorectal Surgery. --- Gastroenterology. --- Internal medicine --- Digestive organs --- Tumors --- Diseases --- Càncer colorectal --- Malalties hereditàries --- Oncologia --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Genopaties --- Herència patològica --- Malalties congènites --- Malalties genètiques --- Malalties genotípiques --- Trastorns congènits --- Trastorns genètics --- Malalties --- Amiotròfia neural progressiva de Charcot-Marie-Tooth --- Corea de Huntington --- Errors congènits del metabolisme --- Esferocitosi hereditària --- Facomatosis --- Fibrosi quística --- Hemofília --- Malaltia de von Willebrand --- Síndrome d'Aicardi-Goutières --- Síndrome de Noonan --- Genètica mèdica --- Patologia molecular --- Càncer de còlon --- Càncer de recte --- Càncer gastrointestinal --- Colorectal Neoplasms, Hereditary Nonpolyposis. --- Chemoprevention.
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Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Cancer research. --- Immunology. --- Medicine. --- Cancer Research. --- Biomedicine, general. --- Health Workforce --- Immunobiology --- Life sciences --- Serology --- Cancer research --- Cancer --- Research. --- Colonic Neoplasms. --- Colorectal Neoplasms --- immunology. --- Cancer of the Colon --- Colon Neoplasms --- Colonic Cancer --- Neoplasms, Colonic --- Cancer of Colon --- Colon Cancer --- Cancer, Colon --- Cancer, Colonic --- Cancers, Colon --- Cancers, Colonic --- Colon Cancers --- Colon Neoplasm --- Colonic Cancers --- Colonic Neoplasm --- Neoplasm, Colon --- Neoplasm, Colonic --- Neoplasms, Colon --- Càncer colorectal --- Investigació mèdica --- Tractament adjuvant del càncer --- Immunologia --- Biologia --- Complements (Immunitat) --- Immunofarmacologia --- Immunologia clínica --- Immunologia de la trasplantació --- Neuroimmunologia --- Resposta immunitària --- Sistema immunitari --- Teràpia adjuvant del càncer --- Tractaments adjuvants del càncer --- Teràpies adjuvants del càncer --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Càncer de còlon --- Càncer de recte --- Càncer gastrointestinal
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Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Cancer research. --- Immunology. --- Medicine. --- Cancer Research. --- Biomedicine, general. --- Health Workforce --- Immunobiology --- Life sciences --- Serology --- Cancer research --- Colon (Anatomy) --- Cancer --- Diagnosis. --- Treatment. --- Colorectal Neoplasms. --- Colonic Neoplasms. --- Cancer of the Colon --- Colon Neoplasms --- Colonic Cancer --- Neoplasms, Colonic --- Cancer of Colon --- Colon Cancer --- Cancer, Colon --- Cancer, Colonic --- Cancers, Colon --- Cancers, Colonic --- Colon Cancers --- Colon Neoplasm --- Colonic Cancers --- Colonic Neoplasm --- Neoplasm, Colon --- Neoplasm, Colonic --- Neoplasms, Colon --- Colorectal Carcinoma --- Colorectal Tumors --- Neoplasms, Colorectal --- Colorectal Cancer --- Cancer, Colorectal --- Cancers, Colorectal --- Carcinoma, Colorectal --- Carcinomas, Colorectal --- Colorectal Cancers --- Colorectal Carcinomas --- Colorectal Neoplasm --- Colorectal Tumor --- Neoplasm, Colorectal --- Tumor, Colorectal --- Tumors, Colorectal --- Càncer colorectal --- Epidemiologia --- Tractament adjuvant del càncer --- Terapia --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Quimioteràpia --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Teràpia adjuvant del càncer --- Tractaments adjuvants del càncer --- Teràpies adjuvants del càncer --- Salut pública --- Comorbiditat --- Epidèmies --- Epidemiologia molecular --- Farmacoepidemiologia --- Morbiditat --- Malalties --- Càncer de còlon --- Càncer de recte --- Càncer gastrointestinal
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