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Breast cancer research on postage stamps. --- Fund raising

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Breast cancer research on postage stamps. --- Postage stamps --- Law and legislation

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This book provides a detailed description of the most common techniques used in breast cancer research, with a special emphasis on the study of the normal breast as the basis for understanding the pathological processes in this organ. The authors have poured their experience in the field of breast cancer research into this book, and described the process of handling and interpreting the complex organ that is the human breast using original data and unique material collected over the years.  They have established the concept of normality of the human breast and the morphological parameters to be used for distinguishing the normal from the diseased breast. The quality of the breast tissue obtained from autopsy material vs. core biopsies are carefully detailed and discussed, showing the morphological differences among the specimens according to their collection site. The use of laser capture microdissection and tissue microarray is described in detail and discussed with special references to the problems faced when the normal breast is under study. A chapter dedicated to the use of breast cancer cell lines is crafted around the importance of each cell line and its particularities for in vitro studies. In addition, the authors explore the new concept that cancer originates from two main cell types, basal and luminal cells . Particular attention is given to the study of the phenotypes commonly used for determining cell transformation, either spontaneously or by induced chemical agents. A companion chapter using in vivo models provides the adequate tools for those interested in studying the early events of cancer initiation, progression and metastasis. Special emphasis is given to the analysis of cells either by Flow cytometry and immuno-fluorescence techniques and the great potential of the use of in situ hybridization to study RNA transcripts. The book also features an original analysis of the putative markers of stem cells in breast cancer using immuno-cytochemical techniques, their interpretation and correlation with the prognosis of the disease. The last two chapters of the book are engaged in the utilization of RNA and DNA sequencing techniques and their values in understanding the physiological differences in the human breast, as well as the utilization of epigenetic methodologies in the understanding of the normal human breast. The authors have established the methodological basis for studying the human breast in its normal and pathological conditions providing a unique set of tools and valuable references for researchers pursuing a deeper understanding of the human breast.

Breast --- Cancer --- Research. --- Psychological aspects. --- Breast cancer research on postage stamps --- Oncology. --- Medicine. --- Proteomics. --- Gene expression. --- Cancer Research. --- Molecular Medicine. --- Biomedicine general. --- Gene Expression. --- Genes --- Genetic regulation --- Molecular biology --- Proteins --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Expression --- Health Workforce --- Cancer research. --- Molecular biology. --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Cancer research. --- Laboratory medicine. --- Medical biochemistry. --- Molecular biology. --- Cancer Research. --- Laboratory Medicine. --- Medical Biochemistry. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pathology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Cancer research --- Breast --- Cancer --- Research. --- Breast cancer research on postage stamps --- Càncer de mama --- Investigació mèdica

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Most deaths from carcinomas are caused by the hematogenous dissemination of cancer cells to distant organs and the eventual development of metastases. When found in the bone marrow or peripheral blood of carcinoma patients, occult cancer cells are referred to as disseminated tumor cells (DTCs) or circulating tumor cells (CTCs). CTCs and DTCs are considered surrogates of minimal residual disease, i.e., the presence of malignant cells in distant organs that are undetectable by conventional imaging and laboratory tests used for tumor staging after curative surgery of the primary tumor.   In this book, leading investigators in the field provide up-to-date information on a series of important questions, including:   -  How can the study of minimal residual disease and CTCs help us to better understand breast cancer metastasis? -  What technologies are available for the detection and characterization of CTCs and DTCs, and what are their relative merits? -  How are DTCs and CTCs relevant to clinical research and practice? - What is the role of other blood-based biomarkers such as circulating endothelial cells and circulating nucleic acids? -  What are the challenges in drug and biomarker co-development and the use of CTCs for companion diagnostic development?   This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Breast -- Cancer. --- Breast -- Cancer -- Diagnosis. --- Breast Neoplasms. --- Neoplasm, Residual. --- Neoplastic Cells, Circulating. --- Neoplastic Processes --- Cells --- Breast Diseases --- Neoplasms by Site --- Neoplasms --- Pathologic Processes --- Anatomy --- Skin Diseases --- Skin and Connective Tissue Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Neoplasm Metastasis --- Neoplasm, Residual --- Breast Neoplasms --- Neoplastic Cells, Circulating --- Medicine --- Health & Biological Sciences --- Oncology --- Breast --- Cancer --- Research. --- Tumors --- Breasts --- Medicine. --- Cancer research. --- Gynecology. --- Oncology. --- Pathology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Cancer Research. --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Gynaecology --- Generative organs, Female --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Excision --- Treatment --- Chest --- Large-breasted women --- Breast cancer research on postage stamps --- Oncology  . --- Gynecology . --- Cancer. --- Cancer Therapy. --- Cancer Biology. --- Treatment. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cancer therapy --- Cancer treatment --- Therapy