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Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.

Models of human brain disorder --- neuronal circuit dynamics --- Neuroanatomy --- Zebrafish --- Behavior

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Psychiatry --- Brain --- Psychiatry. --- Brain Diseases. --- Diseases --- Diseases. --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Psychiatrists --- Psychiatrist --- Cerebrum --- Mind --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Central nervous system --- Head

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Pediatric neurology. --- Brain Diseases. --- Infant, Newborn. --- Nervous system --- Neurology --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Diseases

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Brain --- Brain Diseases. --- Aging. --- Diseases --- Age factors. --- Aging, Biological --- Biological Aging --- Senescence --- Mutation Accumulation --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Cerebrum --- Mind --- Central nervous system --- Head --- Nervous system

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Geriatrics --- Neuropathology --- Aging. --- Aged. --- Brain Diseases. --- Geriatric Psychiatry. --- Psychiatry, Geriatric --- Psychogeriatrics --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Elderly --- Longevity --- Aging, Biological --- Biological Aging --- Senescence --- Mutation Accumulation --- Aging --- Aged --- Brain Diseases --- Geriatric Psychiatry