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Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Bones --- Bone metastasis. --- Cancer. --- Bone Neoplasms. --- Cancer --- Treatment. --- Bone Neoplasms --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Metastasis

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Nous avons souhaité une nouvelle édition sans refonte complète de cet ouvrage, car le succès de la première édition montre que le principe de ce livre est bien adapté à une prise en charge multidisciplinaire de cette pathologie complexe. L'actualisation des progrès techniques réalisés tant sur le plan diagnostique que thérapeutique était pourtant nécessaire. Deux sujets méritent une attention particulière : la place de l'IRM dans la stratégie diagnostique et thérapeutique et la place de la chirurgie vertébrale dans la stratégie globale de la prise en charge de patients atteints de métastase ve

Spinal Neoplasms --- Bone metastasis --- Spine --- Métastases osseuses --- Colonne vertébrale --- secondary. --- Cancer --- Bone metastasis. --- Cancer. --- Métastases osseuses --- Colonne vertébrale --- EPUB-LIV-FT LIVMEDEC LIVSANTE SPRINGER-B --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Bones --- Metastasis

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Bones --- Tumors --- Treatment. --- Thermotherapy. --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Osteology --- Musculoskeletal system --- Bone --- Skeleton --- Bone Neoplasms. --- Microwaves --- therapeutic use. --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Ossos --- Termoteràpia

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"Bone Metastases: A Translational and Clinical Approach" serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Bone metastasis. --- Bones -- Cancer. --- Bone metastasis --- Neoplastic Processes --- Bone Diseases --- Neoplasms by Site --- Neoplasms --- Pathologic Processes --- Musculoskeletal Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Bone Neoplasms --- Neoplasm Metastasis --- Medicine --- Health & Biological Sciences --- Oncology --- Bones --- Cancer. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Metastasis --- Cancer --- Oncology  . --- Tumors --- Cancer research

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Bone metastasis occurs in 60 to 85% of all breast, prostate, and lung cancer patients and is responsible for increasing morbidity. In Bone Metastasis: Experimental and Clinical Therapeutics, leading bone metastasis experts from around the world explain the molecular underpinnings of the process, review current treatment approaches, and outline future therapeutic strategies. On the basic science side, the authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. On the therapeutic side, the authors discuss various strategies that appear to have promise and are currently deployed in treatment or at the experimental stage. They show how the treatment of bone metastases may need to be individualized through a combination of surgical, radiation, and/or pharmacological maneuvers. Their analysis of various pharmacogenomic parameters and tissue environmental factors sets the stage for progress beyond the current standards of using radiation and/or bisphosphonates for palliation. State-of-the-art and innovative, Bone Metastasis: Experimental and Clinical Therapeutics elucidates for all those involved-whether in research or clinical treatment of bone-seeking cancers-the biological processes and therapeutic advances that are already generating significant improvement in the cancer clinic.

Bone Neoplasms --- Neoplasm Metastasis. --- Bone metastasis. --- Métastases osseuses --- secondary. --- Cancer -- Molecular aspects. --- Cancer -- Pathophysiology. --- Bone metastasis --- Bone Diseases --- Neoplasms by Site --- Neoplastic Processes --- Neoplasms --- Pathologic Processes --- Musculoskeletal Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Neoplasm Metastasis --- Medicine --- Health & Biological Sciences --- Oncology --- Bones --- Cancer. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Metastasis --- Cancer --- Oncology  .