Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Endothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments. Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to-date review of the vascular functions of the endothelium and its role in key areas of cardiovascular disease. It focuses on evidence from studies in humans.

Vascular endothelium. --- Vascular endothelium --- Blood vessel endothelium --- Blood-vessels --- Endothelium, Vascular --- Endothelium --- Endothelins --- Pathophysiology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Presents a review of the advances in research on the vascular endothelium. This book discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and considers specific pathologies and their treatment.

Vascular endothelium. --- Blood vessel endothelium --- Blood-vessels --- Endothelium, Vascular --- Endothelium --- Endothelins --- Cardiology. --- Toxicology. --- Human physiology. --- Pharmacology/Toxicology. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Heart --- Internal medicine --- Toxicology --- Diseases --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Currently, the cellular and molecular mechanisms governing the development and regulation of the vasculature are studied in­ tensely and the field is rapidly progressing. Recently, novel growth factors and growth factor receptors specifically acting on endothelial cells have been discovered. Through these factors, communication networks are established between endothelial cells, the basement membrane and the pericytes; this interplay is critical for the regulated development and maintenance of the vasculature. The awareness that deregulated angiogenesis con­ tributes to the progression of a number of diseases, such as cancer and inflammatory diseases, has clearly spurred the field to move forward. The focus of this book is on two important classes of endothelial cell specific growth factors, the vascular endothelial growth factor (VEGF) family, and the angiopoietins, and on their mechanisms of action. The reader will find up-to-date, fo­ cused reviews, which give the current picture, and indicate future directions. I would like to honor Dr. Judah Folkman for his important contributions to the establishment of the field and thank him for his support. Lena Claesson-Welsh List of Contents N. FERRARA Vascular Endothelial Growth Factor: Molecular and Biological Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . M. G. PERSICO, V. VINCENTI and T. DIPALMA Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PIGF) . . . . . . . . . . . . . . . . . 31 U. ERIKSSON and K. ALiTALO Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors. . . . . . . . . 41 M. SHIBUYA, N. ITo and L. CLAESSON-WELSH Structure and Function of Vascular Endothelial Growth Factor Receptor-I and -2 . . . . . . . . . . . . . . . . . . 59 J. TAIPALE, T. MAKINEN, E. ARIGHI, E.

Angiogenesis --- Croissance [Facteurs de ] --- Facteurs de croissance --- Factoren [Groei] --- Groeifactoren --- Growth factors --- Growth substances --- Neovascularisatie --- Neovascularization --- Néovascularisation --- Vascularisatie [Neo] --- Vascularisation [Néo] --- Endothelial Growth Factors --- Proteins --- Pathologic --- Endothelial Growth Factors. --- Proteins. --- Pathologic. --- Blood-vessels --- Growth --- Immunology. --- Cell biology. --- Cancer research. --- Molecular biology. --- Internal medicine. --- Cell Biology. --- Cancer Research. --- Molecular Medicine. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Vascular endothelium. --- Blood vessel endothelium --- Endothelium, Vascular --- Endothelium --- Endothelins

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.

Vascular endothelium --- Endothelium, Vascular. --- Endothelial Cells. --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Capillary Endothelial Cells --- Lymphatic Endothelial Cells --- Vascular Endothelial Cells --- Capillary Endothelial Cell --- Cell, Capillary Endothelial --- Cell, Endothelial --- Cell, Lymphatic Endothelial --- Cell, Vascular Endothelial --- Cells, Capillary Endothelial --- Cells, Endothelial --- Cells, Lymphatic Endothelial --- Cells, Vascular Endothelial --- Endothelial Cell --- Endothelial Cell, Capillary --- Endothelial Cell, Lymphatic --- Endothelial Cell, Vascular --- Endothelial Cells, Capillary --- Endothelial Cells, Lymphatic --- Endothelial Cells, Vascular --- Lymphatic Endothelial Cell --- Vascular Endothelial Cell --- Capillary Endothelium --- Vascular Endothelium --- Capillary Endotheliums --- Endothelium, Capillary --- Endotheliums, Capillary --- Endotheliums, Vascular --- Vascular Endotheliums --- Blood vessel endothelium --- Blood-vessels --- Endothelium, Vascular --- Endothelium --- Endothelins --- Cancer. --- Endothelial cells. --- Endotheliocytes --- Epithelial cells --- Vascular endothelium. --- Endothelial Cells --- Neovascularization, Pathologic --- Neoplasms --- blood supply