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This volume presents techniques and recent developments in biochemical approaches to study glutamatergic neurotransmission. This book contains detailed discussions on tracing neuronal pathways, functional or spectroscopic imaging, optogenetic or pharmacological tools, and extracellular neurochemistry in experimental clinical models. The chapters cover topics such as: identification of glutamatergic neurons in a discrete brain area, tools to study dynamics of single ionotropic receptors, in vivo extracellular glutamate monitoring in preclinical research using biosensors, capillary electrophoresis and liquid chromatography, and potential brain glutamatergic clinical biomarkers in biofluids and tissues. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Biochemical Approaches for Glutamatergic Neurotransmission is a valuable resource for researchers studying glutamate neurochemistry.

Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Neurotransmissors --- Bioquímica clínica --- Manuals de laboratori --- Bioquímica de les malalties --- Bioquímica mèdica --- Bioquímica patològica --- Patobioquímica --- Bioquímica --- Bioquímica clínica veterinària --- Química clínica --- Substàncies neurotransmissores --- Transmissors de l'impuls nerviós --- Transmissors sinàptics --- Neuroquímica --- Neurotransmissió --- Dopamina --- Endorfines --- Noradrenalina --- Òxid nítric --- Serotonina --- Neuropèptids --- Receptors de neurotransmissors --- Tècniques de laboratori --- Norepinefrina

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This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals. Consisting of three sections, the book delves into recent biocomputing and bioinformatics protocols, state-of-the art modern biophysical, electrophoretic, and chromatographic methods and high-throughput screening approaches, as well as detailed protocols and examples of the inhibition analysis and evaluation of selected enzymes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Targeting Enzymes for Pharmaceutical Development: Methods and Protocols serves as a vital reference for academics and industry professionals working on expanding our understanding of the wide range of important enzyme targets. The chapter “Enzyme–Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Enzims --- Farmacologia molecular --- Biologia molecular --- Farmacologia --- Biocatalitzadors --- Ferments --- Catalitzadors --- Proteïnes --- Coenzims --- Enzims al·lostèrics --- Enzims microbians --- Fibrinolítics --- Hidrolases --- Iduronat-2-sulfatasa --- Inducció enzimàtica --- Isoenzims --- Malt --- Metal·loenzims --- Oxidoreductases --- Transferases --- Biocatàlisi --- Fermentació --- Pharmaceutical chemistry. --- Enzymology. --- Medicinal chemistry. --- Pharmaceutics. --- Medicinal Chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Biochemistry --- Enzymes --- Enzimologia --- Bioquímica clínica --- Química farmacèutica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria --- Bioquímica de les malalties --- Bioquímica mèdica --- Bioquímica patològica --- Patobioquímica --- Bioquímica --- Bioquímica clínica veterinària --- Química clínica --- Enzimologia clínica

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Clinical biochemistry --- Biochemistry. --- Chemistry, Clinical. --- Bioquímica clínica --- Bioquímica --- Química clínica --- Clinical biochemistry. --- Revistes. --- Clinical Chemistry --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Chemistry, Clinical --- Bioquímica. --- Bioquímica clínica. --- Química clínica. --- Periodicals --- Revistes --- fast --- (OCoLC)fst00864329 --- Pathology --- Clinical Chemistry Tests --- Chemistry, Analytic --- Anàlisis clíniques --- Diagnòstic bioquímic --- Diagnòstic químic --- Química mèdica --- Diagnòstic de laboratori --- Anàlisi d'orina --- Anàlisi de sang --- Enzimologia clínica --- Valors de referència (Medicina) --- Laboratoris clínics --- Bioquímica de les malalties --- Bioquímica mèdica --- Bioquímica patològica --- Patobioquímica --- Bioquímica clínica veterinària --- Química biològica --- Química fisiològica --- Biologia --- Medicina --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica