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Book
Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA
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ISBN: 9811087466 9811087458 Year: 2018 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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Abstract

In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book. .


Periodical
Journal of molecular recognition
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ISSN: 10991352 09523499

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Keywords

Molecular recognition --- Reconnaissance moléculaire --- Structure moléculaire --- Protéines de liaison --- Molecular recognition. --- Models, Molecular. --- Molecular Conformation. --- Molecular Sequence Data. --- Périodiques. --- Molecular Sequencing Data --- Sequence Data, Molecular --- Data, Molecular Sequence --- Data, Molecular Sequencing --- Sequencing Data, Molecular --- 3D Molecular Structure --- Configuration, Molecular --- Molecular Structure, Three Dimensional --- Three Dimensional Molecular Structure --- Molecular Configuration --- 3D Molecular Structures --- Configurations, Molecular --- Conformation, Molecular --- Conformations, Molecular --- Molecular Configurations --- Molecular Conformations --- Molecular Structure, 3D --- Molecular Structures, 3D --- Structure, 3D Molecular --- Structures, 3D Molecular --- Molecular Models --- Model, Molecular --- Molecular Model --- Biomolecular recognition --- Recognition, Molecular --- Models, Molecular --- Molecular Conformation --- Molecular Sequence Data --- Molecular Structure --- Carrier Proteins --- Binding Protein --- Binding Proteins --- Transport Proteins --- Protein, Binding --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- Structure, Molecular --- Molecular Structures --- Structures, Molecular --- Ligand binding (Biochemistry) --- Molecular biology --- Protein Binding --- Receptors, Transferrin --- Molecular Structure. --- Carrier Proteins. --- Carrier Protein --- Transport Protein --- Protein, Carrier --- Protein, Transport --- Models, Molecular . --- Protein Binding. --- Molecular structure. --- Carrier proteins. --- Molecular structure --- Carrier proteins --- Structure moléculaire. --- Protéines de liaison. --- molecular structure. --- Periodicals. --- Binding proteins --- Transport proteins --- Biological transport --- Protein binding --- Proteins --- Chemical structure --- Structural bioinformatics

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