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In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.

Drug delivery systems. --- Proteins. --- Pharmacology. --- Medicinal chemistry. --- Biomaterials. --- Drug Delivery. --- Protein Biochemistry. --- Medicinal Chemistry. --- Biomaterials-Proteins.

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This book provides a comprehensive overview of recent developments to valorize fish waste as a source of useful products. In the first few chapters, an introductory section unearths global fish waste production, its detrimental effects and its role in the circular economy. The next section of the book discusses recent applications of fish waste and by-products utilization for the production of useful products such as fertilizers, biogas, biodiesel, fish sauce, enzymes and many more. This book will serve as an important source of recent research developments and applications of fish waste generated at different stages of fish processing. This book will also act as an important reference to the research group conducting research on fish and fish by-product utilization and valorization. .

Proteins. --- Biomaterials. --- Green chemistry. --- Refuse and refuse disposal. --- Biomaterials-Proteins. --- Green Chemistry. --- Waste Management/Waste Technology. --- Fisheries --- By-products.

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Molecular self-assembly has been exploited by nature for developing the higher functional macromolecular structures of both the genome and proteome. Inspired by nature, there has been a surge of research, in the last two decades, for the molecular engineering of peptide-based self-assembling nanostructures, adopting the bottom-up design approach. This book gives the reader an overview on the design rules for de novo self-assembling peptide and reviews the diverse range of bioinspired peptide nanostructures such as β-sheet and β-hairpin, α-helical and coiled coil, self-assembling short peptides and peptidomimetics, collagen-based and elastin-like peptides, silk peptides, peptide amphiphiles, peptides co-polymers and others. The book also covers the wide variety of responsive and functional biomaterials that have been innovated based on those nanostructures for various applications ranging from tissue engineering, therapeutics and drug delivery to antimicrobial nanomaterials and biosensors. Finally, the book also discusses the peptide bionanomaterials global market and the future of the emerging industry. Chapter “Characterization of Peptide-Based Nanomaterials” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Proteins. --- Biomaterials. --- Nanobiotechnology. --- Nanoscience. --- Self-assembly (Chemistry). --- Protein Biochemistry. --- Biomaterials-Proteins. --- Nanophysics. --- Self-assembly. --- Self-organizing systems --- Nano science --- Nanoscale science --- Nanosciences --- Science --- Bionanotechnology --- Biotechnology --- Nanotechnology --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Nanostructured materials. --- Peptides --- Self-assembly (Chemistry) --- Biotechnology.