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Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.

Enzymes --- Biotransformation (Metabolism) --- Biotechnology. --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Metabolism --- Pharmacology --- Enzymology. --- Drugs --- Biotransformation --- Pharmaceutical Preparations --- Metabolism. --- metabolism

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The application of recombinant DNA technology to industrial fermentation and the production of enzymes over the last 20 years has produced a host of useful chemical and biochemical substances. In Microbial Enzymes and Biotransformations, leading experts in enzyme manipulation describe in detail their cutting-edge techniques for the screening, evolution, production, immobilization, and application of enzymes. These readily reproducible methods can be used to improve enzyme function by directed evolution, to covalently immobilize enzymes, to microencapsulate enzymes and cells, and to manufacture enzymes for human health, nutrition, and environmental protection. Two overview chapters consider microorganisms as a source of metabolic and enzymatic diversity, and enzymes in the fast-moving field of enzyme biosensors. The protocols follow the successful Methods in Biotechnology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Microbial Processes and Products, provides laboratory procedures for a wide range of processes and products mediated by microorganisms. Comprehensive and highly practical, Microbial Enzymes and Biotransformations offers laboratory and industrial scientists a wealth of proven enzymatic protocols that show clearly how to go from laboratory results to successful industrial applications.

Microbial enzymes --- Microbial biotechnology --- Biotransformation (Metabolism) --- Biotechnology --- Biotransformation (Metabolism) -- Laboratory manuals. --- Microbial biotechnology -- Laboratory manuals. --- Microbial enzymes -- Biotechnology -- Laboratory manuals. --- Biotransformation --- Activation, Metabolic --- Metabolic activation --- Microorganisms --- Industrial microbiology --- Biotechnological microorganisms --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolism --- Pharmacology --- Microbiology. --- Microbial biology --- Biology

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A comprehensive and consolidated account of how microorganisms can play a significant role in degrading and detoxifying toxic, carcinogenic, mutagenic, and teratogenic compounds is detailed in this book. Moreover, the volume deals with all aspects of microbial degradation, ranging from screening methods for the degradative microorganisms, processes of degradation, strain improvement for enhanced biodegradation, and elimination of undesirable compounds to improving health and environmental protection strategies. The book will provide an opportunity for scientists in the areas of microbiology,

Microbial metabolism --- Biotransformation (Metabolism) --- Xenobiotics --- Metabolic detoxication --- Biodegradation --- Xenobiotics - Biodegradation. --- Microbial metabolism. --- Foreign chemical compounds --- Foreign compounds --- Xenobiotic compounds --- Biochemistry --- Chemicals --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Metabolism --- Pharmacology --- Bacterial metabolism --- Metabolism, Bacterial --- Microorganisms --- Biodegradation. --- Metabolic detoxification. --- Physiology

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The use of enzymes – employed either as isolated enzymes, crude protein extracts or whole cells – for the transformation of non-natural organic c- pounds is not an invention of the twentieth century: they have been used for more than one hundred years. However,the object of most of the early research was totally different from that of the present day. Whereas the elucidation of biochemical pathways and enzyme mechanisms was the main driving force for the early studies,in contrast it was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic c- pounds was recognized. This trend was particularly well enhanced by the recommendation of the FDA-guidelines (1992) with respect to the use of chiral bioactive agents in enantiopure form. During the last two decades, it has been shown that the substrate tolerance of numerous biocatalysts is often much wider than previously believed. Of course,there are many enzymes which are very strictly bound to their natural substrate(s). They play an important role in metabolism and they are gener- ly not applicable for biotransformations. On the other hand, an impressive number of biocatalysts have been shown to possess a wide substrate tolerance by keeping their exquisite catalytic properties with respect to chemo-, reg- and, most important, enantio-selectivity. This made them into the key tools for biotransformations.

Activation [Metabolic ] --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Biotransformatie (Metabolisme) --- Biotransformation (Metabolism) --- Biotransformation (Metabolisme) --- Metrabolic activation --- Animal Physiology --- Biosynthèse --- Chemistry --- Biotechnology --- Chemistry, Organic --- Chemical engineering --- Enzymes --- Organic compounds --- Biotechnology. --- Synthesis. --- Organic chemistry. --- Biochemistry. --- Organic Chemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Genetic engineering --- Organic chemistry --- Composition --- Enzymes - Biotechnology. --- Organic compounds - Synthesis. --- BIOCHEMICAL MOLECULES --- ENZYMES --- CATALYSIS --- REACTIONS

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This volume provides a clear understanding of how microbes, following their degradative processes, contribute maximally to the benefit of mankind through biotransformations of waste materials as well as a wide variety of health-risk compounds. The book contains twenty four chapters contributed by leading scientists from different parts of the world, covering various aspects of bioremediation of xenobiotics such as toxic, carcinogenic, teratogenic, and mutagenic compounds, which include halogenated aromatics, derivatives of heavy metals, microbial toxins, tannins, dyes, sulfur compounds o

Biodegradation. --- Biotransformation (Metabolism) --- Metabolic detoxification. --- Bioremediation. --- Biodegradation --- Pollution --- Environmental biotechnology --- Metabolic conjugation --- Chemicals --- Detoxication, Metabolic --- Detoxification, Metabolic --- Metabolic detoxication --- Metabolism --- Pharmacology --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Biochemistry --- Decomposition (Chemistry) --- Microbiology --- Biocorrosion --- Biodecay --- Biodecomposition --- Biodeterioration --- Biological corrosion --- Biological decay --- Biological decomposition --- Biological degradation --- Decay, Biological --- Decomposition (Biology) --- Degradation, Biological --- Metabolic detoxification