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This dissertation explores the development and design of organs-on-chips, dynamic cell culture devices that mimic organ function in vitro. These devices are intended to improve the assessment of drug toxicity and efficacy during the early stages of the drug development process, aiming to better predict clinical trial outcomes. The work discusses the complexity of cell environments and highlights how three-dimensional cell cultures, mechanical stimuli, and other advanced methodologies can enhance cell functionality compared to traditional two-dimensional static models. The research includes examples of 3D spheroids, hydrogels, and electroosmotic pumps, contributing to the field with a conceptual design process for creating new organ-on-chip prototypes. The intended audience includes researchers and professionals in biotechnology, biomedical engineering, and related fields.

Biochips. --- Microfluidics. --- Biochips --- Microfluidics

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DNA microarrays --- Biochips --- Biosensors

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Microarray Analysis is a natural outgrowth of the author's teaching and research into the field of microarray processing, a fast growing and developing field. The book highlights the development of various microarray analysis tools and the applications of the technology towards disease prevention and eradication. The goal is to illustrate the many sequencing methods in place, and to show the various applications of these methods. This book will show how the biochemical reactions involved in the different steps of the cure process can be studied using microarray methods. Examples will be provided throughout the text of various disease states, including the spread of cystic fibrosis in children consanguineous marriages in Saudi Arabia, genetic disorders, and autoimmune disorders. The protocols from sample preparation to confocal scanning microscopy and detectors using photo multiplier tubes, biochip manufacturing methods, advances in sequencing methods, microfluids, electrophoretic methods are discussed in detail. The Polymerase chain reaction, a technique used to amplify and simultaneously quantify a targeted DNA molecule is explored. The criteria for choosing the best surface to use for microarray analysis is elloborated. Additionally, Microarray Analysis: Biochips and Eradication of Disease will feature the statistical methods needed for analysis of DNA data from microarray analysis, including shotgun and next generation sequencing.

DNA microarrays. --- DNA biochips --- Microarrays, DNA --- Biochips --- Immobilized nucleic acids

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Mathematical statistics --- DNA microarrays. --- DNA biochips --- Microarrays, DNA --- Biochips --- Immobilized nucleic acids --- DNA microarrays

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DNA microarrays. --- DNA --- DNA biochips --- Microarrays, DNA --- Biochips --- Immobilized nucleic acids --- Deoxyribonucleic acid synthesis --- Synthesis.