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Biological techniques --- General biochemistry --- Biochemistry --- Laboratory manuals --- Biochemistry - Laboratory manuals
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Analytical biochemistry --- Biochemistry --- Laboratory manuals --- 577.1 --- biochemie --- laboratoriumproef --- Laboratory manuals. --- Biochemistry - Laboratory manuals --- Biochemistry - laboratory manuals
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General biochemistry --- Biochemistry --- Laboratory manuals --- Biochemistry. --- -Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- -Laboratory manuals --- Biochemistry - Laboratory manuals --- Biochemistry - laboratory manuals
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Analytical biochemistry --- Biochemistry --- Laboratory manuals --- Biochemistry. --- Biochemie --- Practica --- Biochemie. --- Practica. --- Laboratory manuals. --- Biochemistry - laboratory manuals --- Biochemistry - Laboratory manuals --- BIOCHEMISTRY --- LABORATORY MANUALS
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Biochemistry --- Laboratory manuals --- Analytical biochemistry --- Biochemistry. --- -Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Laboratory manuals. --- laboratory manuals --- -Laboratory manuals --- laboratory manuals. --- -Biology --- Biological chemistry --- Biochemistry - Laboratory manuals --- Biochemistry - laboratory manuals
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Spectrometric and optical chemical analysis --- fysicochemie --- Analysis of pharmaceuticals --- Organic spectroscopy --- Chemistry, Organic --- Fluorimetry --- Biochemistry --- Colorimetry --- Pharmaceutical Preparations --- Chemistry Techniques, Analytical --- analysis --- Biochemistry - laboratory manuals --- Colorimetry - laboratory manuals --- Pharmaceutical Preparations - analysis - laboratory manuals --- Chemistry Techniques, Analytical - laboratory manuals
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The multidisciplinary science of chemical proteomics studies how small molecules of synthetic or natural origin bind to proteins and modulate their function. In Chemical Proteomics: Methods and Protocols, expert researchers in the field provide key techniques to investigate chemical proteomics focusing on analytical strategies, how probes are generated, techniques for the discovery of small molecule targets and the probing of target function, and small molecule ligand and drug discovery. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chemical Proteomics : Methods and Protocols seeks to provide methodologies that will contribute to a wider application of chemical proteomics methods in biochemical and cell biological laboratories.
Biochemistry. --- Proteomics. --- Protein Science. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Molecular biology --- Proteins --- Composition --- Proteomics - Laboratory manuals --- Biochemistry - Laboratory manuals --- Proteomics --- Biochemistry
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Although parallel synthesis combined with high-throughput screening has made it easier to generate highly potent drug candidates, many of these compounds never make the grade because they either prove to be unsafe or lack the necessary physicochemical and pharmacokinetic properties. In Optimization in Drug Discovery: In Vitro Methods, a panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world provide proven solutions to this expensive problem with a collection of cutting-edge experimental protocols for early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Optimization in Drug Discovery: In Vitro Methods systematically collects and describes the key methods for uncovering-as early in the discovery stage as possible-those defects that can eliminate candidate drugs from preclinical and clinical development.
Pharmaceutical chemistry --- Physical biochemistry --- Drugs --- Drug Evaluation, Preclinical --- Testing --- methods --- Drugs -- Testing -- Laboratory manuals. --- Pharmaceutical chemistry -- Laboratory manuals. --- Physical biochemistry -- Laboratory manuals. --- Investigative Techniques --- Drug Discovery --- Evaluation Studies as Topic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Methods --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Pharmacy. --- Chemistry --- Medicine --- Materia medica --- Pharmacology --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Pharmacy --- Biophysical chemistry --- Biochemistry --- Physical organic chemistry --- Pharmaceutical chemistry - Laboratory manuals --- Physical biochemistry - Laboratory manuals --- Drugs - Testing - Laboratory manuals --- Drug Evaluation, Preclinical - methods
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