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Beta-lactamases

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beta-Lactamases --- pharmacology

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This dissertation by Åse Östholm Balkhed focuses on the epidemiology of extended-spectrum beta-lactamase (ESBL)-producing bacteria, particularly in a Swedish county. It examines antibiotic resistance patterns, detection methods, and risk factors associated with ESBL-producing pathogens such as Escherichia coli. The study highlights the prevalence and regional dominance of CTX-M enzymes and reports on antibiotic susceptibility testing, noting limited treatment options due to multidrug resistance. A significant finding is the correlation between international travel and the acquisition of ESBL-producing bacteria, with older travelers at higher risk. The research underscores the need for improved diagnostics, hygiene, and rational antibiotic use to combat the spread of resistant bacteria.

Beta lactamases. --- Escherichia coli. --- Beta lactamases --- Escherichia coli

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beta-Lactamases --- Anti-Bacterial Agents --- pharmacology. --- BETA-LACTAMASES --- ANTIBIOTICS --- pharmacodynamics --- pharmacodynamics. --- Antibiotics --- Beta-lactamases --- Pharmacodynamics. --- pharmacology

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Escherichia coli --- Phenotype. --- Genotype. --- Cattle. --- Microbial Sensitivity Tests. --- beta-Lactam Resistance. --- beta-Lactamases. --- genetics