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Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development. Complex chemical processes often involve coupling between dynamics at vastly different length and time scales, as well as coupling of different physical models. The multiscale and multiphysics nature of those problems calls for delicate modeling approaches. This book showcases recent contributions in this field, from the development of modeling methodology to its application in supporting the design, development, and optimization of engineering processes.

Technology: general issues --- wood dust --- nasal epithelia --- VOCs --- M1dG --- reactive oxygen species (ROS) --- nucleotide excision repair (NER) --- base excision repair (BER) --- oxidative DNA damage --- DNA damage response and repair network --- immune response --- autoimmunity --- systemic lupus erythematosus --- systemic sclerosis --- rheumatoid arthritis --- oxidative stress --- abasic sites --- chromatin organization --- apoptosis --- DNA damage --- general anesthesia --- neuraxial anesthesia --- comet assay --- chronic myeloid leukemia --- genetic instability --- DNA double-strand breaks --- DNA damage response --- benzo[a]pyrene --- BPDE-DNA adduct --- silymarin --- detoxification --- Nrf2 --- PXR --- DNA repair --- base excision repair (BER)glycosylases --- colorectal cancer --- reactive oxygen species --- metabolic adaptation --- drug resistance --- cancer --- thyroid --- thyroid cancer --- volcano --- metals --- metallome --- carcinogens --- hormesis --- environment pollution --- metal biocontamination --- n/a --- Diamond-Blackfan anemia --- 8-oxoguanine --- inflammatory cytokines --- erythrocyte lifespan

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Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development. Complex chemical processes often involve coupling between dynamics at vastly different length and time scales, as well as coupling of different physical models. The multiscale and multiphysics nature of those problems calls for delicate modeling approaches. This book showcases recent contributions in this field, from the development of modeling methodology to its application in supporting the design, development, and optimization of engineering processes.

Technology: general issues --- wood dust --- nasal epithelia --- VOCs --- M1dG --- reactive oxygen species (ROS) --- nucleotide excision repair (NER) --- base excision repair (BER) --- oxidative DNA damage --- DNA damage response and repair network --- immune response --- autoimmunity --- systemic lupus erythematosus --- systemic sclerosis --- rheumatoid arthritis --- oxidative stress --- abasic sites --- chromatin organization --- apoptosis --- DNA damage --- general anesthesia --- neuraxial anesthesia --- comet assay --- chronic myeloid leukemia --- genetic instability --- DNA double-strand breaks --- DNA damage response --- benzo[a]pyrene --- BPDE-DNA adduct --- silymarin --- detoxification --- Nrf2 --- PXR --- DNA repair --- base excision repair (BER)glycosylases --- colorectal cancer --- reactive oxygen species --- metabolic adaptation --- drug resistance --- cancer --- thyroid --- thyroid cancer --- volcano --- metals --- metallome --- carcinogens --- hormesis --- environment pollution --- metal biocontamination --- Diamond-Blackfan anemia --- 8-oxoguanine --- inflammatory cytokines --- erythrocyte lifespan

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Mutation (Biology) --- DNA repair --- DNA repair. --- Mutation --- DNA Repair --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- Mutations --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- DNA Damage --- Polymorphism, Restriction Fragment Length --- Genetics --- Variation (Biology) --- Biochemical genetics --- Antimutagens --- Mutation. --- DNA Repair.

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DNA Repair. --- DNA Repair --- DNA repair --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Biochemical genetics --- Antimutagens --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair --- drug effects. --- DNA repair. --- drug effects --- Molecular biology

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Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.

Genomics. --- Genomes. --- Genetics --- Genomics --- Haploidy --- Genome research --- Genomes --- Molecular genetics --- Research --- DNA Repair. --- Genomic Instability. --- Epigenesis, Genetic. --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Genome Instability --- Genome Stability --- Genomic Stability --- Genome Instabilities --- Genome Stabilities --- Genomic Instabilities --- Genomic Stabilities --- Instabilities, Genome --- Instabilities, Genomic --- Instability, Genome --- Instability, Genomic --- Stabilities, Genome --- Stabilities, Genomic --- Stability, Genome --- Stability, Genomic --- Chromothripsis --- DNA Sequence, Unstable --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair