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Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.

Brain Ischemia. --- Blood-Brain Barrier. --- Stroke. --- Cerebrovascular Disorders. --- Blood flow --- Cerebral ischemia --- Cerebrovascular disease --- Apoplexy --- Brain --- Cerebral circulation disorders --- Cerebral vascular accident --- Cerebrovascular accident --- Cerebrovascular disorders --- Cerebrovascular syndrome --- CVA (Disease) --- Stroke --- Neglect (Neurology) --- Brain ischemia --- Ischemia --- Blood --- Body fluid flow --- Hemodynamics --- Cerebrovascular Diseases --- Cerebrovascular Insufficiency --- Cerebrovascular Occlusion --- Brain Vascular Disorders --- Intracranial Vascular Disorders --- Vascular Diseases, Intracranial --- Brain Vascular Disorder --- Cerebrovascular Disease --- Cerebrovascular Disorder --- Cerebrovascular Insufficiencies --- Cerebrovascular Occlusions --- Disease, Cerebrovascular --- Diseases, Cerebrovascular --- Insufficiencies, Cerebrovascular --- Insufficiency, Cerebrovascular --- Intracranial Vascular Disease --- Intracranial Vascular Diseases --- Intracranial Vascular Disorder --- Occlusion, Cerebrovascular --- Occlusions, Cerebrovascular --- Vascular Disease, Intracranial --- Vascular Disorder, Brain --- Vascular Disorder, Intracranial --- Vascular Disorders, Brain --- Vascular Disorders, Intracranial --- CVA (Cerebrovascular Accident) --- Cerebrovascular Accident, Acute --- Cerebrovascular Stroke --- Stroke, Acute --- Cerebral Stroke --- Cerebrovascular Accident --- Cerebrovascular Apoplexy --- Vascular Accident, Brain --- Acute Cerebrovascular Accident --- Acute Cerebrovascular Accidents --- Acute Stroke --- Acute Strokes --- Apoplexy, Cerebrovascular --- Brain Vascular Accident --- Brain Vascular Accidents --- CVAs (Cerebrovascular Accident) --- Cerebral Strokes --- Cerebrovascular Accidents --- Cerebrovascular Accidents, Acute --- Cerebrovascular Strokes --- Stroke, Cerebral --- Stroke, Cerebrovascular --- Strokes --- Strokes, Acute --- Strokes, Cerebral --- Strokes, Cerebrovascular --- Vascular Accidents, Brain --- Encephalopathy, Ischemic --- Ischemia, Cerebral --- Cerebral Ischemia --- Ischemic Encephalopathy --- Brain Ischemias --- Cerebral Ischemias --- Ischemia, Brain --- Ischemias, Cerebral --- Ischemic Encephalopathies --- Blood-vessels --- Diseases --- Flow --- Circulation --- Brain Ischemia --- Blood-Brain Barrier --- Cerebrovascular Disorders --- Brain Diseases --- Cardiovascular System --- Vascular Diseases --- Central Nervous System Diseases --- Cardiovascular Diseases --- Central Nervous System --- Anatomy --- Nervous System --- Nervous System Diseases --- Medicine --- Health & Biological Sciences --- Neurology --- Brain-Blood Barrier --- Hemato-Encephalic Barrier --- Barrier, Blood-Brain --- Barrier, Brain-Blood --- Barrier, Hemato-Encephalic --- Barriers, Blood-Brain --- Barriers, Brain-Blood --- Barriers, Hemato-Encephalic --- Blood Brain Barrier --- Blood-Brain Barriers --- Brain Blood Barrier --- Brain-Blood Barriers --- Hemato Encephalic Barrier --- Hemato-Encephalic Barriers --- Astrocytes --- Capillary Permeability --- Cerebrospinal Fluid --- Neurology . --- Neurosurgery. --- Cardiology. --- Neurology. --- Heart --- Internal medicine --- Nerves --- Neurosurgery --- Nervous system --- Neuropsychiatry --- Surgery