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The book focuses on a global problem challenging the health systems. Trypanosoma cruzi infections are transmitted by cone-nosed triatomine bugs, by blood transfusion and congenitally from mothers to their offspring. The American Trypanosomiasis affects 20 million people; among them a significant parcel (< 1/3) will develop Chagas disease in the heart and digestive tract, where the immune system effector cells destroy target host cells. Genotype modifications resulting from transfer of minicircle sequence kDNA from the parasite into the host ́s genome may explain the autoimmune pathogenesis.

Chagas' disease. --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis

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Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions.

Chagas' disease. --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis

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Este admirável volume reuniu especialistas de diversos campos do conhecimento para comentar a importância de 15 artigos clássicos associados à descoberta científica de Carlos Chagas, que completou cem anos em 2009. A obra indica novas diretrizes e os desafios que ainda cercam a doença na atualidade. Organizado por pesquisadoras do Instituto Oswaldo Cruz (IOC/Fiocruz) e da Casa de Oswaldo Cruz (COC/Fiocruz), pela coordenadora de eventos da Fiocruz e por um ex-vice-presidente de pesquisa da instituição, que juntos formaram uma rede para definir quais seriam os principais artigos clássicos que demarcaram o avanço das pesquisas sobre doença de Chagas, o livro contextualiza-os em relação ao centenário e “…assim surge…, coletivo, histórico e atual”, nas palavras de uma das organizadoras.

Chagas' disease --- Diseases --- History. --- Transmission. --- Causes and theories of causation. --- Aetiology --- Etiology --- Pathology --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis --- History of medicine

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Ainda hoje estima-se que na América Latina aproximadamente 13 milhões de pessoas desconheçam estarem infectadas e sobrevivendo com o vetor da doença de Chagas, de acordo com a ONG Médicos Sem Fronteiras. Embora o Brasil tenha sido considerado livre da transmissão pela principal espécie de vetor em 2006, pela OMS, é importante que novas gerações de estudantes das áreas da saúde coletiva possam conhecer o processo histórico e o percurso pelo qual a descoberta científica pôde ser identificada, reconhecida e legitimada pela comunidade médico-científica como 'doença'. O livro em questão analisa o processo de transformação da doença de Chagas em 'doença' e reconstrói a trajetória de Carlos Chagas e seus estudos sobre a enfermidade. Tem por objetivo, nas palavras da autora, “refletir sobre a dimensão histórica e social desse processo, no qual este fato científico foi sendo produzido e validado em estreita relação com vários grupos e esferas da vida social brasileira”. A obra conjuga história social da medicina, história social da ciência e do pensamento social brasileiro, uma vez que a própria caracterização da doença de Chagas foi, ao longo de boa parte do século XX, associada à imagem do Brasil.

Chagas' disease --- Diseases --- Public health --- History. --- Transmission. --- Causes and theories of causation. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Aetiology --- Etiology --- Pathology --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Trypanosomiasis

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This Brief provides a comprehensive overview of Trypanosoma cruzi, a parasite that is traditionally considered as exclusively vectorborne, but can be foodborne, and may lead to outbreaks of Chagas disease in consumers. The characteristics of Trypanosoma cruzi and the clinical effects of the disease are covered, including documented outbreaks, regional patterns, and epidemiology. The various transmission routes are outlined, but with specific focus on foodborne transmission. A major emphasis of this text is contamination of fruit juices with Trypanosoma cruzi in, a transmission vehicle with increasing significance in the spread of this parasite. Also outlined is the difficulty of establishing a protocol for detection in food samples. Results on survival of Trypanosoma cruzi in food matrices is considered, as well as current risk assessment procedures and regulations. Different approaches to preventing transmission, including inactivation and decontamination are introduced, but also the importance of targeted educational initiatives, and also with a focus on future detection, prevention, and prevention of contamination of foods with this parasite.

Biomedical Engineering --- Health & Biological Sciences --- Foodborne diseases. --- Trypanosoma cruzi. --- Chagas' disease. --- American trypanosomiasis --- Barbiero fever --- Cruz-Chagas disease --- South American trypanosomiasis --- Food-borne diseases --- Foodborne illnesses --- Chemistry. --- Microbiology. --- Food --- Public health. --- Food Science. --- Public Health. --- Applied Microbiology. --- Biotechnology. --- Trypanosomiasis --- Trypanosoma --- Communicable diseases --- Food science. --- Science --- Microbial biology --- Biology --- Microorganisms --- Food—Biotechnology. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Food biotechnology --- Biotechnology --- Genetically modified foods