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Quatrième de couverture : "Le développement continu des résistances bactériennes aux antibiotiques entraîne l'apparition d'infections de plus en plus souvent impossibles à maîtriser. Il en résulte des situations individuelles dramatiques. La phagothérapie, qui utilise des virus singuliers « mangeurs de bactéries » appelés bactériophages, est une réponse à cette évolution inéluctable et préoccupante. La phagothérapie a été développée il y a un siècle, puis abandonnée devant les indéniables succès de l'antibiothérapie. Aujourd'hui, elle redevient un sujet d'actualité face au drame annoncé que pourrait provoquer un retour à l'ère pré-antibiotique. Force est de constater que l'intérêt mondial pour cette ancienne thérapeutique, comme alternative ou complément à l'antibiothérapie, s'amplifie. Mais la phagothérapie doit s'adapter aux sciences biologiques et médicales nouvelles. Ainsi, les bactériophages, considérés comme des médicaments, doivent être produits selon les règles de bonne pratique de fabrication en vigueur, avant d'être admis par les agences nationales. Ils doivent ensuite démontrer leur innocuité et leur efficacité dans des tests expérimentaux. Leur utilisation médicale sera alors autorisée selon des recommandations propres à cette thérapeutique. Cet ouvrage très complet offre les rappels nécessaires en matière de bactériologie, virologie et infectiologie, des notions de biologie moléculaire, et présente les bactériophages et leurs applications thérapeutiques d'un point de vue historique et moderne. Il démontre que la phagothérapie - éprouvée, simple et bon marché -, constitue un espoir pour les victimes d'infections bactériennes, nosocomiales ou autres, de plus en plus souvent sans ressource thérapeutique efficace."
Bacteriophages --- Drug Resistance, Microbial --- Infectious Diseases --- therapeutic use --- drug therapy --- Phage Therapy --- therapy --- Phagothérapie. --- Maladies infectieuses --- Bactéries --- Phagothérapie. --- Infections --- Thérapeutique. --- Résistance aux antibiotiques. --- Thérapie. --- Complementary Therapies --- Drug Resistance, Bacterial --- Communicable Diseases --- Bactériophages --- therapeutic use. --- Bacteriophages - therapeutic use --- Infectious Diseases - therapy --- Complementary Therapies. --- Drug Resistance, Bacterial. --- therapy.
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“Bacteriophages have the potential to stop many if not most life threatening, drug resistant bacterial infections. The Forgotten Cure is a non-stop, cover to cover read.” James D. Watson, Nobel Laureate “A lively tale of killer viruses, superbugs and a magical cure that has all the twists of a cold-war spy novel.” – George Hackett, Newsweek magazine “A marvelous, jargon-free historical account of the genesis, the ups-and-downs, and the current renaissance of phage therapy. The Forgotten Cure ranks at the level of Judson’s Eighth Day of Creation.” Sankar Adhya National Institutes of Health The Forgotten Cure: How a Long Lost Treatment Can Save Lives in the 21st Century Before the arrival of penicillin in the 1940s, phage therapy was one of the few weapons doctors had against bacterial infections. It saved the life of Hollywood legend Tom Mix before being abandoned by Western science. Now, researchers and physicians are rediscovering the treatment, which pits phage viruses against their natural bacterial hosts, as a potential weapon against antibiotic-resistant infections. The Forgotten Cure traces the story of phages from Paris, where they were discovered in 1917; to Tbilisi, Georgia, where one of phage therapy’s earliest proponents died at the hands of Stalin; to the Nobel podium, where prominent scientists have been recognized for breakthroughs stemming from phage research. Today, a crop of biotech startups and dedicated physicians is racing to win regulatory approval for phage therapy before superbugs exhaust the last drug in the medical arsenal. Will they clear the hurdles in time? .
Bacterial diseases -- Alternative treatment. --- Bacteriophages -- Therapeutic use. --- Bacteriophages --- Bacterial diseases --- Drug Resistance, Microbial --- Bacterial Physiological Phenomena --- Viruses --- Bacterial Infections and Mycoses --- Therapeutics --- Microbiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Drug Resistance --- Diseases --- Organisms --- Pharmacological Phenomena --- Phenomena and Processes --- Physiological Phenomena --- Biological Therapy --- Bacterial Infections --- Drug Resistance, Bacterial --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Therapeutic use --- Alternative treatment --- Bacteriophages. --- Medical virology. --- Bacteriophage --- Phages --- Medicine. --- Immunology. --- Laboratory medicine. --- Medical microbiology. --- Biomedicine. --- Medical Microbiology. --- Laboratory Medicine. --- Medical microbiology --- Virology --- Virus diseases --- Lysogeny --- Transduction
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