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Ten percent of breast cancers are of hereditary genetic origin, with a majority of cancers carrying a mutation inactivating BRCA1 or BRCA2 genes. These genes encode enzymes that are normally involved in the initiation of DNA damage repair. Therefore, about 80% of women carrying BRCA1/2 mutations develop breast cancer during their life. Once the mutation is detected, the prophylactic strategy consists in a close follow-up possibly assorted to preventive surgery. In case of a declared cancer, the therapeutic treatment is the common one for breast cancer. Yet, specific treatment is possible. Indeed, poly (ADP-ribose) polymerase (PARP) inhibitors are a new class of anticancer agents with a high cytotoxic potential against BRCA-mutated cells linked to their ability to further repress DNA damage repair, thus increasing the chance of lethal mutations in cancers cells (synthetic lethality). Our graduation thesis details the major PARP inhibitors (Iniparib®, Olaparib®, Niraparib®, Veliparib®), having already shown therapeutic activity in clinical situation. Dix pourcents des cancers du sem sont d'origine génétique héréditaire, avec une majorité de cancers porteurs d;une mutation inactivatrice des gènes BRCA 1 ou BRCA2. Ces gènes codent des enzymes normalement impliquées dans l'initiation de la réparation des lésions affectant l'ADN. En conséquence, environ 80% des patientes porteuses de mutations BRCAl/2 développent un cancer du sein au cours de leur vie. En cas de mutation avérée, la stratégie prophylactique consiste en un suivi régulier associé éventuellement à une chirurgie préventive. En cas de cancer déclaré, le traitement appliqué est le traitement classique du cancer du sein. Or, un traitement spécifique est possible. En effet, les inhibiteurs de poly(ADP­ ribose) polymérases (PARP) sont une nouvelle classe d'anticancéreux à fort potentiel cytotoxique pour les cellules BRCA mutées, puisqu'en réprimant la réparation de l'ADN ils augmentent la chance de la survenue de mutations létales pour les cellules cancéreuses (létalité synthétique). Notre mémoire détaille les principaux inhibiteurs de PARP (Iniparib®, Olaparib®, Niraparib®, et Veliparib®) ayant à ce j our montré une activité thérapeutiq ue en situation clinique.

RNA Polymerase I --- Breast Neoplasms --- BRC-1 protein, C elegans

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Yugoslav War, 1991-1995 --- Yugoslav War, 1991-1995 --- Yugoslav War, 1991-1995 --- Brčko (Bosnia and Hercegovina)

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70

Kwaliteitszorg. --- Production management --- Business policy --- IKZ (integrale kwaliteitszorg) --- Academic collection --- 658.56 --- BRC Global Standard --- CE-markering --- EMAS --- HACCP --- IKZ --- ISO 14000 --- ISO 9000 --- Kwaliteitsbeheersing --- Kwaliteitszorg --- Planning --- 658.56 Quality control. Control of tool issue, materials, products etc. --- Quality control. Control of tool issue, materials, products etc. --- Kwaliteitsbeleid --- Kwaliteitsmanagement --- Integrale kwaliteitszorg --- Kwaliteit --- Kwaliteit (proceskenmerk)

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Concrete is one of the most widely used construction material in the word today. The research in concrete follows the environment impact, economy, population and advanced technology. This special issue presents the recent numerical study for research in concrete. The research topic includes the finite element analysis, digital concrete, reinforcement technique without rebars and 3D printing.

Technology: general issues --- History of engineering & technology --- cementitious composite --- nano-SiO2 --- PVA fiber --- durability evaluation --- adaptive neuro-fuzzy inference system --- aggregate type --- specimen shape --- specimen size --- compressive strength --- concrete mechanical properties --- concrete composites --- waste metalised polypropylene fibres --- durability --- sulphate and acid attacks --- palm oil fuel ash --- fiber-reinforced concrete --- blast resistance --- lattice discrete particle model-fiber --- damage mode --- contact detonation --- concrete brick --- FGD gypsum --- construction and demolition waste --- oil palm trunks --- sugarcane bagasse ash --- sensitivity analysis --- gene expression programming --- multiple linear and non-linear regression --- green concrete --- concrete-filled steel tube (CFST) --- axial capacity --- genetic engineering programming (GEP) --- Euler's buckling load --- GEP-based model --- calcium silicate hydrate --- simulation --- concrete --- corrosion inhibitor --- grand canonical Monte Carlo method --- molecular dynamics --- adsorption --- coupled RBSM and solid FEM model --- PBL shear connector --- shear strength --- lateral pressures --- failure mechanism --- bamboo-reinforced concrete (BRC) --- stiffness prediction --- artificial neural network (ANN) --- radioactive waste --- long-term performance --- degradation --- modeling --- finite element analysis --- mechanical properties --- mechanisms --- diffusion --- material properties --- sodium alginate --- basalt fiber --- temperature --- impact resistance --- pre-packed aggregate fibre-reinforced concrete --- strength --- long-term shrinkage --- microstructure --- waste polypropylene fibres --- cohesion --- angle of shear deformation --- Mohr-Coulomb model --- induced tensile strength --- concrete samples --- Brazilian test --- finite element method (FEM) --- artificial neural networks --- confined concrete --- strength model --- FRP --- strain model --- RMSE --- forta fibers --- synthetic fibers --- hybrid fiber reinforced concrete --- constitutive modeling --- uniaxial test --- slump test --- pore structure --- water absorption --- MIP --- fractal dimension --- pore connectivity --- T-shaped reinforced concrete beams --- CFRP --- numerical analysis --- non-destructive test (NDT) --- elastic wave --- air-entrained rubberized concrete --- stress-strain curve --- concrete failure --- damage of material --- effective modulus of elasticity --- effective stress --- hybrid-fiber-reinforced concrete --- shaft lining --- numerical simulation --- orthogonal test --- ultimate capacity --- cementitious composite --- nano-SiO2 --- PVA fiber --- durability evaluation --- adaptive neuro-fuzzy inference system --- aggregate type --- specimen shape --- specimen size --- compressive strength --- concrete mechanical properties --- concrete composites --- waste metalised polypropylene fibres --- durability --- sulphate and acid attacks --- palm oil fuel ash --- fiber-reinforced concrete --- blast resistance --- lattice discrete particle model-fiber --- damage mode --- contact detonation --- concrete brick --- FGD gypsum --- construction and demolition waste --- oil palm trunks --- sugarcane bagasse ash --- sensitivity analysis --- gene expression programming --- multiple linear and non-linear regression --- green concrete --- concrete-filled steel tube (CFST) --- axial capacity --- genetic engineering programming (GEP) --- Euler's buckling load --- GEP-based model --- calcium silicate hydrate --- simulation --- concrete --- corrosion inhibitor --- grand canonical Monte Carlo method --- molecular dynamics --- adsorption --- coupled RBSM and solid FEM model --- PBL shear connector --- shear strength --- lateral pressures --- failure mechanism --- bamboo-reinforced concrete (BRC) --- stiffness prediction --- artificial neural network (ANN) --- radioactive waste --- long-term performance --- degradation --- modeling --- finite element analysis --- mechanical properties --- mechanisms --- diffusion --- material properties --- sodium alginate --- basalt fiber --- temperature --- impact resistance --- pre-packed aggregate fibre-reinforced concrete --- strength --- long-term shrinkage --- microstructure --- waste polypropylene fibres --- cohesion --- angle of shear deformation --- Mohr-Coulomb model --- induced tensile strength --- concrete samples --- Brazilian test --- finite element method (FEM) --- artificial neural networks --- confined concrete --- strength model --- FRP --- strain model --- RMSE --- forta fibers --- synthetic fibers --- hybrid fiber reinforced concrete --- constitutive modeling --- uniaxial test --- slump test --- pore structure --- water absorption --- MIP --- fractal dimension --- pore connectivity --- T-shaped reinforced concrete beams --- CFRP --- numerical analysis --- non-destructive test (NDT) --- elastic wave --- air-entrained rubberized concrete --- stress-strain curve --- concrete failure --- damage of material --- effective modulus of elasticity --- effective stress --- hybrid-fiber-reinforced concrete --- shaft lining --- numerical simulation --- orthogonal test --- ultimate capacity

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Concrete is one of the most widely used construction material in the word today. The research in concrete follows the environment impact, economy, population and advanced technology. This special issue presents the recent numerical study for research in concrete. The research topic includes the finite element analysis, digital concrete, reinforcement technique without rebars and 3D printing.

cementitious composite --- nano-SiO2 --- PVA fiber --- durability evaluation --- adaptive neuro-fuzzy inference system --- aggregate type --- specimen shape --- specimen size --- compressive strength --- concrete mechanical properties --- concrete composites --- waste metalised polypropylene fibres --- durability --- sulphate and acid attacks --- palm oil fuel ash --- fiber-reinforced concrete --- blast resistance --- lattice discrete particle model-fiber --- damage mode --- contact detonation --- concrete brick --- FGD gypsum --- construction and demolition waste --- oil palm trunks --- sugarcane bagasse ash --- sensitivity analysis --- gene expression programming --- multiple linear and non-linear regression --- green concrete --- concrete-filled steel tube (CFST) --- axial capacity --- genetic engineering programming (GEP) --- Euler’s buckling load --- GEP-based model --- calcium silicate hydrate --- simulation --- concrete --- corrosion inhibitor --- grand canonical Monte Carlo method --- molecular dynamics --- adsorption --- coupled RBSM and solid FEM model --- PBL shear connector --- shear strength --- lateral pressures --- failure mechanism --- bamboo-reinforced concrete (BRC) --- stiffness prediction --- artificial neural network (ANN) --- radioactive waste --- long-term performance --- degradation --- modeling --- finite element analysis --- mechanical properties --- mechanisms --- diffusion --- material properties --- sodium alginate --- basalt fiber --- temperature --- impact resistance --- pre-packed aggregate fibre-reinforced concrete --- strength --- long-term shrinkage --- microstructure --- waste polypropylene fibres --- cohesion --- angle of shear deformation --- Mohr–Coulomb model --- induced tensile strength --- concrete samples --- Brazilian test --- finite element method (FEM) --- artificial neural networks --- confined concrete --- strength model --- FRP --- strain model --- RMSE --- forta fibers --- synthetic fibers --- hybrid fiber reinforced concrete --- constitutive modeling --- uniaxial test --- slump test --- pore structure --- water absorption --- MIP --- fractal dimension --- pore connectivity --- T-shaped reinforced concrete beams --- CFRP --- numerical analysis --- non-destructive test (NDT) --- elastic wave --- air-entrained rubberized concrete --- stress-strain curve --- concrete failure --- damage of material --- effective modulus of elasticity --- effective stress --- hybrid-fiber-reinforced concrete --- shaft lining --- numerical simulation --- orthogonal test --- ultimate capacity --- n/a --- Euler's buckling load --- Mohr-Coulomb model