Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Through the use of extended graphical abstracts and some traditional text-only abstracts this collection provides, a record of and roadmap to, the research presented at The Tenth International Catecholamine Symposium (XICS) held in September of 2012. Organized around ten general themes, each is introduced by a short overview identifying interesting research programs, results and potential areas of growth. The collection is a roadmap to key research and future opportunities for new catecholamine research programs and will be of interest to neuroscientists and clinical neurologists interested

Catecholamine. --- Catecholamines -- Analysis. --- Medicine. --- Catecholamines --- Pharmacology --- Research --- Biogenic Monoamines --- Receptors, Biogenic Amine --- Publication Formats --- Receptors, G-Protein-Coupled --- Amines --- Organic Chemicals --- Science --- Receptors, Cell Surface --- Publication Characteristics --- Biogenic Amines --- Receptors, Neurotransmitter --- Chemicals and Drugs --- Membrane Proteins --- Natural Science Disciplines --- Proteins --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Receptors, Catecholamine --- Congresses --- Biomedical Research --- Catecholamines. --- Clinical sciences --- Medical profession --- Sympathins --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biogenic amines --- Chromaffin cells --- Hormones --- Health Workforce

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Dopaminergic neurons. --- Dopaminergic neurons --- Neurotransmitter Agents --- Neurons --- Dopamine --- Physiology --- Catecholamines --- Biological Science Disciplines --- Molecular Mechanisms of Pharmacological Action --- Physiological Effects of Drugs --- Cells --- Nervous System --- Biogenic Monoamines --- Pharmacologic Actions --- Anatomy --- Natural Science Disciplines --- Amines --- Biogenic Amines --- Chemical Actions and Uses --- Disciplines and Occupations --- Organic Chemicals --- Chemicals and Drugs --- Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences --- Dopamine neurons --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Dopaminergic mechanisms --- Health Workforce --- Biomedicine, general.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cortico-subcortical dynamics in Parkinson’s disease aims to integrate key pathophysiological aspects underlying Parkinson’s disease. The volume offers a broad spectrum of opinions on how chronic dopamine depletion affects cortico-subcortical dynamics, especially how disruptions of the non-dopaminergic systems resulting from chronic dopaminergic degeneration could lead to the functional alterations observed in parkinsonism. About the Editor: Dr. Kuei Y. Tseng is Assistant Professor in the Department of Cellular and Molecular Pharmacology at Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA.

Brain --Pathophysiology. --- Parkinson's disease. --- Parkinson's disease --- Brain --- Biological Science Disciplines --- Catecholamines --- Parkinsonian Disorders --- Central Nervous System --- Neurodegenerative Diseases --- Nervous System --- Amines --- Natural Science Disciplines --- Biogenic Monoamines --- Movement Disorders --- Basal Ganglia Diseases --- Nervous System Diseases --- Diseases --- Central Nervous System Diseases --- Biogenic Amines --- Organic Chemicals --- Anatomy --- Brain Diseases --- Disciplines and Occupations --- Chemicals and Drugs --- Parkinson Disease --- Dopamine --- Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Pathophysiology --- Pathophysiology. --- Cerebrum --- Mind --- Palsy, Shaking --- Paralysis agitans --- Parkinson disease --- Parkinsonism --- Shaking palsy --- Medicine. --- Human physiology. --- Neurosciences. --- Pharmacology. --- Neurology. --- Neurobiology. --- Medicine & Public Health. --- Human Physiology. --- Pharmacology/Toxicology. --- Central nervous system --- Head --- Extrapyramidal disorders --- Toxicology. --- Neurosciences --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Human biology --- Medical sciences --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Neuropsychiatry --- Toxicology --- Neurology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scientists in their fields, explore the life cycle of dopaminergic neurons from their birth to death, the cause of Parkinson's disease, the second most common and disabling condition in the elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is symptomatic rather than preventive. The mechanisms by which alterations cause neuronal death, new therapeutic approaches and the latest evidence of a possible de novo neurogenesis in the SNc are reviewed and singled out in different chapters. This book bridges basic science and clinical practice and will prepare the reader for the next few years, which will surely be eventful in terms of the progress of dopamine research.

Dopaminergic neurons. --- Neurotransmitters. --- Parkinson’s disease -- Treatment. --- Substantia nigra. --- Dopaminergic neurons --- Substantia nigra --- Neurotransmitters --- Dopamine --- Parkinson Disease --- Substantia Nigra --- Physiology --- Neurons --- Catecholamines --- Neurodegenerative Diseases --- Biological Science Disciplines --- Cells --- Parkinsonian Disorders --- Tegmentum Mesencephali --- Nervous System --- Mesencephalon --- Anatomy --- Movement Disorders --- Biogenic Monoamines --- Natural Science Disciplines --- Basal Ganglia Diseases --- Amines --- Nervous System Diseases --- Brain Diseases --- Brain --- Disciplines and Occupations --- Central Nervous System Diseases --- Diseases --- Biogenic Amines --- Organic Chemicals --- Brain Stem --- Central Nervous System --- Chemicals and Drugs --- Neuroscience --- Neurology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Black substance (Neuroanatomy) --- Body of Vicq d'Azyr --- Locus niger (Neuroanatomy) --- Nigra (Neuroanatomy) --- Nucleus niger (Neuroanatomy) --- Soemmering's ganglion --- Dopamine neurons --- Medicine. --- Neurology. --- Medicine & Public Health. --- Dopaminergic mechanisms --- Nervous system --- Neuropsychiatry --- Neurology .

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Histamine. --- Histamine -- Metabolism. --- Histamine -- Physiological effect. --- Histamine -- Toxicology. --- Receptors, Histamine. --- Histamine --- Inflammation --- Pathologic Processes --- Immune System Diseases --- Ethylamines --- Histamine Agents --- Imidazoles --- Biogenic Monoamines --- Receptors, Biogenic Amine --- Autacoids --- Biological Science Disciplines --- Neurotransmitter Agents --- Natural Science Disciplines --- Pathological Conditions, Signs and Symptoms --- Biogenic Amines --- Receptors, Neurotransmitter --- Azoles --- Amines --- Inflammation Mediators --- Receptors, Cell Surface --- Diseases --- Heterocyclic Compounds, 1-Ring --- Membrane Proteins --- Organic Chemicals --- Molecular Mechanisms of Pharmacological Action --- Physiological Effects of Drugs --- Biological Factors --- Disciplines and Occupations --- Proteins --- Chemicals and Drugs --- Pharmacologic Actions --- Heterocyclic Compounds --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Histamine Antagonists --- Receptors, Histamine --- Hypersensitivity --- Physiology --- Physiological effect --- Pathophysiology --- Mediators --- Physiological effect. --- Pathophysiology. --- Mediators. --- Inflammatory mediators --- Mediators of inflammation --- Medicine. --- Human physiology. --- Biomedicine. --- Biomedicine general. --- Human Physiology. --- Human biology --- Medical sciences --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Biomolecules --- Biogenic amines --- Antihistamines --- Health Workforce --- Biomedicine, general.