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Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.

B cells.

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B cells

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B cells. --- Immunological tolerance.

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This dissertation by Josefine Åhsberg delves into the molecular mechanisms governing lymphoid restriction with a particular focus on B cell development. It explores the interplay between extracellular signaling and transcription factor networks, notably the roles of FLT3 and IL7R in the proliferation and commitment of common lymphoid progenitors (CLPs) to the B lineage. The work highlights the critical functions of transcription factors such as EBF1 and Pax5 in lineage restriction and the development of hematopoietic cells. Through detailed investigations using mouse models, the thesis provides insights into the genetic mutations affecting cell type development, contributing to a broader understanding of hematopoietic development in both health and disease.

B cells. --- Hematopoiesis.

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B cells --- Antigen presenting cells