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book (6)

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Book
Differentiation of B lymphocytes
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ISBN: 3540174702 0387174702 3642718531 3642718515 9780387174709 9783540174707 Year: 1987 Volume: 135 Publisher: Berlin: Springer,

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Dissertation
MiRNAs and their target genes in B cell lymphomas.
Authors: ---
ISBN: 9789036739481 Year: 2009 Publisher: Zutphen Wöhrmann

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Dissertation
Analysis of immunoglobulin gene rearrangements and translocations in B cell neoplasia by DNA fiber FISH

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Book
Towards individualized therapy for multiple myeloma
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ISBN: 1282442619 9786612442612 9812835806 9789812835802 9781282442610 Year: 2009 Publisher: Hackensack, NJ World Scientific

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This very provocative book takes the reader on a "think-out-of-the-box" journey through the development of a treatment regimen for multiple myeloma called "dtZ". It is a firsthand account of how more than 50 patients with myeloma were given a non-toxic, precisely-targeted, anti-cancer treatment that was specifically adapted to their individual cancers. These Individualized Anti-Cancer Targeted Therapies (smart bombs) have produced amongst the best responses as well as survival rates for myeloma. Accordingly, the author argues that some patients might even have been "cured" of their cancers. Th

CD5 B cells in development and disease
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ISBN: 0897667026 Year: 1992 Volume: 651 Publisher: New York (N.Y.) : New York academy of sciences,

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Book
Genetic and molecular epidemiology of multiple myeloma
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ISBN: 1461446597 1489998659 1299197205 1461446600 Year: 2013 Publisher: New York, NY : Springer,

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This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.  Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.


Book
Multiple myeloma
Authors: ---
ISBN: 3540857710 3540857729 3642267998 Year: 2011 Publisher: Berlin ; Heidelberg : Springer-Verlag,

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Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.


Book
Decoding the Antibody Repertoire : High Throughput Sequencing of Multiple Transcripts from Single B Cells
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ISBN: 3319585185 3319585177 Year: 2017 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.

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