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B cells --- Antigens, Differentiation, B-Lymphocyte. --- Cell differentiation --- B cells. --- Cell differentiation.
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MicroRNAs --- Hodgkin Disease --- Gene Expression Regulation --- B-Lymphocyte Subsets --- metabolism --- genetics
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Chromosome Breakage --- Genes, bcl-2 --- Gene Rearrangement --- Lymphoma, Follicular --- B-Lymphocyte Subsets --- Lymphoma, Non-Hodgkin --- genetics --- immunology
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This very provocative book takes the reader on a "think-out-of-the-box" journey through the development of a treatment regimen for multiple myeloma called "dtZ". It is a firsthand account of how more than 50 patients with myeloma were given a non-toxic, precisely-targeted, anti-cancer treatment that was specifically adapted to their individual cancers. These Individualized Anti-Cancer Targeted Therapies (smart bombs) have produced amongst the best responses as well as survival rates for myeloma. Accordingly, the author argues that some patients might even have been "cured" of their cancers. Th
Multiple myeloma. --- B cells --- B cell neoplasia --- B cell neoplasms --- B cell tumors --- B lymphocyte tumors --- Lymphomas --- Kahler's disease --- Plasma cell myeloma --- Monoclonal gammopathies --- Plasmacytoma --- Tumors. --- Tumors
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Antigens, CD. --- B-Lymphocytes. --- Cluster of Differentiation Antigens --- Cluster of Differentiation Markers --- Differentiation Antigens, Leukocyte, Human --- Leukocyte Differentiation Antigens, Human --- CD Antigens --- B cells --- CD antigens --- Antigens, CD --- B-Lymphocytes --- Congresses. --- congresses. --- B-Cells --- Bursa-Dependent Lymphocytes --- B Cells --- B Lymphocytes --- B-Cell --- B-Lymphocyte --- Bursa Dependent Lymphocytes --- Bursa-Dependent Lymphocyte --- Lymphocyte, Bursa-Dependent --- Lymphocytes, Bursa-Dependent --- CD glycoproteins --- CD molecules --- CD receptors --- CD surface immunoglobulin ligands --- Differentiation antigens, Human leukocyte --- Human leukocyte differentiation antigens --- Leukocyte differentiation antigens, Human --- Cell surface antigens --- Fc receptors --- Glycoproteins --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Antigen presenting cells --- Lymphocytes --- Congresses --- B cells - Congresses. --- CD antigens - Congresses. --- B Cell --- B Lymphocyte --- CD Antigen --- Cluster of Differentiation Antigen --- Cluster of Differentiation Marker --- Antigen Cluster, Differentiation --- Antigen, CD --- Differentiation Antigen Cluster --- Differentiation Marker Cluster --- Marker Cluster, Differentiation --- B-Cells, Lymphocyte --- B Cells, Lymphocyte --- B-Cell, Lymphocyte --- Lymphocyte B-Cell --- Lymphocyte B-Cells
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This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.
Cell differentiation. --- Cytology. --- Human genetics. --- Medicine. --- Neoplasms -- Epidemiology. --- Neoplasms -- Prevention & control. --- Oncology. --- Multiple myeloma --- Biology --- Neoplasms, Plasma Cell --- Neoplasms by Histologic Type --- Biological Science Disciplines --- Neoplasms --- Natural Science Disciplines --- Disciplines and Occupations --- Diseases --- Genetics --- Multiple Myeloma --- Medicine --- Health & Biological Sciences --- Oncology --- B cells --- Epidemiology. --- Tumors. --- B cell neoplasia --- B cell neoplasms --- B cell tumors --- B lymphocyte tumors --- Kahler's disease --- Plasma cell myeloma --- Cancer research. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Human Genetics. --- Lymphomas --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Heredity, Human --- Human biology --- Physical anthropology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Cancer research
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Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
B cells -- Tumors. --- Multiple myeloma. --- Multiple myeloma --- Hemostatic Disorders --- Lymphoproliferative Disorders --- Paraproteinemias --- Neoplasms, Plasma Cell --- Blood Protein Disorders --- Immunoproliferative Disorders --- Vascular Diseases --- Neoplasms by Histologic Type --- Hemorrhagic Disorders --- Hematologic Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Neoplasms --- Hemic and Lymphatic Diseases --- Diseases --- Multiple Myeloma --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- B cells --- Tumors. --- B cell neoplasia --- B cell neoplasms --- B cell tumors --- B lymphocyte tumors --- Kahler's disease --- Plasma cell myeloma --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Tumors --- Haematology --- Internal medicine --- Blood --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Lymphomas --- Monoclonal gammopathies --- Plasmacytoma --- Oncology .
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This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.
Medicine. --- Human genetics. --- Antibodies. --- Genetic engineering. --- Biochemistry. --- Cell biology. --- Biomedicine. --- Genetic Engineering. --- Human Genetics. --- Cell Biology. --- Biochemistry, general. --- Immunoglobulins --- B cells --- Analysis. --- Tumors. --- B cell neoplasia --- B cell neoplasms --- B cell tumors --- B lymphocyte tumors --- Antibodies --- Immune globulins --- Immune serum globulin --- Lymphomas --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Monoclonal antibodies. --- Cytology. --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Molecular cloning --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Composition
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