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Research on designing new catalytic systems has been one of the most important fields in modern organic chemistry, and one reason for this is the predominant contribution of catalysis to the concepts of atom economy and green chemistry in the 21st century. Gold, considered catalytically inactive for a long time, is now a fascinating partner of modern chemistry, as scientists such as Bond, Haruta, Hutchings, Ito and Hayashi opened new perspectives for the whole synthetic chemist community. This book presents the major advances in homogeneous catalysis, emphasizing the methodologies that create

Catalysis. --- Gold compounds. --- Auric compounds --- Aurous compounds --- Chemicals --- Activation (Chemistry) --- Chemistry, Physical and theoretical --- Surface chemistry --- 544.43 --- Gold --- Specie --- Native element minerals --- Precious metals --- Transition metals --- Money --- Mechanism of chemical reactions

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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Zinc-finger proteins. --- Zinc-finger proteins --- Gold compounds. --- Inhibitors. --- Auric compounds --- Aurous compounds --- Chemicals --- Zinc fingers --- Zinc proteins --- Chemistry, inorganic. --- Chemistry, Organic. --- RNA-ligand interactions. --- Mass spectrometry. --- Bioorganic chemistry. --- Immunology. --- Inorganic Chemistry. --- Organometallic Chemistry. --- Protein-Ligand Interactions. --- Mass Spectrometry. --- Bioorganic Chemistry. --- Immunobiology --- Life sciences --- Serology --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Organic chemistry --- Chemistry --- Inorganic chemistry --- Inorganic compounds --- Inorganic chemistry. --- Organometallic chemistry . --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Chemistry, Organometallic --- Metallo-organic chemistry