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Drugs --- Dilution --- Homeopathy --- Homeopathy. --- Research --- Attenuations, dilutions, and potencies --- Pharmacy, Therapeutics, & Pharmacology --- Médicaments --- Recherche

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Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.

Atherosclerosis -- Treatment. --- Chemistry. --- Medicine. --- Organometallic compounds. --- Medicine --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Cardiovascular Diseases --- Organic Chemistry --- Atherosclerosis. --- Homeopathy --- Attenuations, dilutions, and potencies. --- High potency (Drugs) --- Organometallic chemistry. --- Biochemistry. --- Organometallic Chemistry. --- Biochemistry, general. --- Biomedicine general. --- Arteriosclerosis --- Chemistry, Organic. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Organic chemistry --- Composition --- Health Workforce --- Organometallic chemistry . --- Biomedicine, general. --- Chemistry, Organometallic --- Metallo-organic chemistry --- Chemistry, Organic

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Since the subject of high dilution effects is still a subject for debate, this volume provides evidence in support of effects from control clinical studies, clinical records from veteran physicians, controlled experiments on animals and plants, and in vitro tests without any organisms (Chapter II). An overview of the methods for preparing drugs at ultra high dilution is also provided as well as the basic principles of homeopathy, which has been alleviating human suffering through the use of these drugs for several hundred years (Chapter I). Chapter III provides physical basis of high dilutions as evidence from the NMR, IR, UV and fluorescence spectra of those drugs. Since water is used as the diluents media, the structure and dynamics of water polymers in relation to high dilution are discussed in order to facilitate easy comprehension of this physical aspect, the basic principles of spectroscopy are also described. Chapter IV focuses on the mechanism of action of potentized drugs in the living system, discussing the structure of the cell, the plasma membrane, the integral proteins on the membrane, the interaction between these proteins and high dilutions and the manifestations of the therapeutic effects of high dilutions. Some aspects, peculiar to homeopathy, such as the chief miasm psora, and the literalities and time modalities of symptoms and drug action are interpreted from a scientific perspective. Chapter IV ends with a brief discussion on water structures and the origin of life to show the natural evolution of high dilution effects. The book not only helps in understanding the physical basis of high dilutions and their mechanism of action in organisms but provides many new avenues of investigation into this interdisciplinary field of science.

Homeopathy --- Dilution. --- Drugs --- Attenuations, dilutions, and potencies. --- Dose-response relationship. --- High potency (Drugs) --- Dose-effect relationship --- Pharmacology --- Chemistry --- Dosage --- Toxicology. --- Biochemistry. --- Microbiology. --- Botany. --- Analytical biochemistry. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Medical Microbiology. --- Plant Sciences. --- Analytical Chemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Biology --- Natural history --- Plants --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Chemicals --- Medicine --- Poisoning --- Poisons --- Composition --- Toxicology --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Pharmacology. --- Medical microbiology. --- Plant science. --- Analytical chemistry. --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect --- Floristic botany