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Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.

Atherosclerosis -- Treatment. --- Chemistry. --- Medicine. --- Organometallic compounds. --- Medicine --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Cardiovascular Diseases --- Organic Chemistry --- Atherosclerosis. --- Homeopathy --- Attenuations, dilutions, and potencies. --- High potency (Drugs) --- Organometallic chemistry. --- Biochemistry. --- Organometallic Chemistry. --- Biochemistry, general. --- Biomedicine general. --- Arteriosclerosis --- Chemistry, Organic. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Organic chemistry --- Composition --- Health Workforce --- Organometallic chemistry . --- Biomedicine, general. --- Chemistry, Organometallic --- Metallo-organic chemistry --- Chemistry, Organic